PHYSICOMECHANICAL PROPERTIES AND RELEASE CHARACTERISTICS OF KETOROLAC TROMETHAMINE FROM CHITOSAN FILMS: EFFECT OF INCLUSION OF DIFFERENT POLYOLS PLASTICIZERS
Zen-aldeen, E., Hussein, A., Ibrahim, M., Amin, M. (2008). PHYSICOMECHANICAL PROPERTIES AND RELEASE CHARACTERISTICS OF KETOROLAC TROMETHAMINE FROM CHITOSAN FILMS: EFFECT OF INCLUSION OF DIFFERENT POLYOLS PLASTICIZERS. EKB Journal Management System, 31(2), 229-247. doi: 10.21608/bfsa.2008.64326
E. A. Zen-aldeen; A. K. Hussein; M. A. Ibrahim; M. A. Amin. "PHYSICOMECHANICAL PROPERTIES AND RELEASE CHARACTERISTICS OF KETOROLAC TROMETHAMINE FROM CHITOSAN FILMS: EFFECT OF INCLUSION OF DIFFERENT POLYOLS PLASTICIZERS". EKB Journal Management System, 31, 2, 2008, 229-247. doi: 10.21608/bfsa.2008.64326
Zen-aldeen, E., Hussein, A., Ibrahim, M., Amin, M. (2008). 'PHYSICOMECHANICAL PROPERTIES AND RELEASE CHARACTERISTICS OF KETOROLAC TROMETHAMINE FROM CHITOSAN FILMS: EFFECT OF INCLUSION OF DIFFERENT POLYOLS PLASTICIZERS', EKB Journal Management System, 31(2), pp. 229-247. doi: 10.21608/bfsa.2008.64326
Zen-aldeen, E., Hussein, A., Ibrahim, M., Amin, M. PHYSICOMECHANICAL PROPERTIES AND RELEASE CHARACTERISTICS OF KETOROLAC TROMETHAMINE FROM CHITOSAN FILMS: EFFECT OF INCLUSION OF DIFFERENT POLYOLS PLASTICIZERS. EKB Journal Management System, 2008; 31(2): 229-247. doi: 10.21608/bfsa.2008.64326

PHYSICOMECHANICAL PROPERTIES AND RELEASE CHARACTERISTICS OF KETOROLAC TROMETHAMINE FROM CHITOSAN FILMS: EFFECT OF INCLUSION OF DIFFERENT POLYOLS PLASTICIZERS

Bulletin of Pharmaceutical Sciences Assiut University
Article 6, Volume 31, Issue 2, December 2008, Page 229-247  XML PDF (930.36 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2008.64326
View on SCiNiTO View on SCiNiTO
Authors
E. A. Zen-aldeen1; A. K. Hussein2; M. A. Ibrahim3; M. A. Amin* 3
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Tanta
2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, El-Menia University, El-Menia
3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut
Abstract
The film-forming ability of chitosan polymer loaded with ketorolac tromethamine (KT) was evaluated. Films were prepared by a casting/solvent evaporation technique from plasticizer - free and plasticizer containing aqueous solutions. Glycerol, sorbitol, and 1-erythritol were used as plasticizers. Solid state of the films was studied by powder X-ray diffractometry (PXRD), and differential scanning calorimetry (DSC). The plasticizing efficiency was evaluated by measuring the physicomechanical properties as modulus of elasticity, tensile strength, percent of elongation and swelling ratio. The medicated films - plasticized or free - were clear and colorless. A plasticizer concentration of 20% (w/w of polymer weight) was sufficient to obtain flexible films with all tested samples. X-ray diffration patterns and DSC thermograms indicated an amorphous state of the films independent on the type of the plasticizer used. The results have showed that, incorporation of different polyols as plasticizers improves the consistency and the physicomechanical properties of the films. The plasticizers effect was dependant on the hydrophilicity and chemical structure of both plasticizer and polymer. The release profile of the drug was also significantly increased by addition of polyols as plasticizers. Moreover, the drug release pattern was found to follow Higuchidiffusion model.
Statistics
Article View: 142
PDF Download: 252