LIPOSOMES AS AN OCULAR DELIVERY SYSTEM FOR FLUCONAZOLE: IN-VIVO STUDY | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 31, Issue 2, December 2008, Page 249-263 PDF (1.11 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2008.64327 | ||||
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| Authors | ||||
| F. S. Habib1; E. A. Fouad1; M. S. Abdel-Rahman2; Dina Fathalla1 | ||||
| 1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Department of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The purpose of this study was to formulate topically effective controlled release ophthalmic fluconazole liposomal formulations using the reverse-phase evaporation technique. Soya bean phosphatidylcholine (PC) and cholesterol (Ch) in specific weight ratios were used. Selected formulations were tested for their in-vivo ocular antifungal effect. These included the neutral, the positively (using stearyl amine) and the negatively (using dicetyl phosphate) charged liposomes. A reproducible model of Candida keratitis in rabbits was performed and the effects of the prepared liposomes were better than a solution of fluconazole. The order of fluconazole liposomal formulations according to the time to achieve complete healing is arranged in a descending order: negatively charged liposomes > positively charged liposomes > neutral liposomes (7:4) > neutral liposomes (5:5) > fluconazole solution. The frequency of instillation was decreased; also, the time of ulcer healing was decreased. It was concluded that the use of liposomes as a drug delivery system could contribute to the enhancement of the effect of fluconazole in the eye. | ||||
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