SYNTHESIS AND STABILITY STUDY ON AN ASPIRIN DERIVATIVE WITH POTENTIAL SELECTIVE COX-2 INHIBITOR
S. A., A., A.M, O. (2008). SYNTHESIS AND STABILITY STUDY ON AN ASPIRIN DERIVATIVE WITH POTENTIAL SELECTIVE COX-2 INHIBITOR. EKB Journal Management System, 4(1), 1-14. doi: 10.21608/blj.2008.64445
Al-Mikhlafi S. A.; Othman A.M. "SYNTHESIS AND STABILITY STUDY ON AN ASPIRIN DERIVATIVE WITH POTENTIAL SELECTIVE COX-2 INHIBITOR". EKB Journal Management System, 4, 1, 2008, 1-14. doi: 10.21608/blj.2008.64445
S. A., A., A.M, O. (2008). 'SYNTHESIS AND STABILITY STUDY ON AN ASPIRIN DERIVATIVE WITH POTENTIAL SELECTIVE COX-2 INHIBITOR', EKB Journal Management System, 4(1), pp. 1-14. doi: 10.21608/blj.2008.64445
S. A., A., A.M, O. SYNTHESIS AND STABILITY STUDY ON AN ASPIRIN DERIVATIVE WITH POTENTIAL SELECTIVE COX-2 INHIBITOR. EKB Journal Management System, 2008; 4(1): 1-14. doi: 10.21608/blj.2008.64445

SYNTHESIS AND STABILITY STUDY ON AN ASPIRIN DERIVATIVE WITH POTENTIAL SELECTIVE COX-2 INHIBITOR

Biochemistry Letters
Article 1, Volume 4, Issue 1, 2008, Page 1-14  XML PDF (391.06 K)
Document Type: Original Article
DOI: 10.21608/blj.2008.64445
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Authors
Al-Mikhlafi S. A.1; Othman A.M2
1Department of medicinal chemistry
2Faculty of Pharmacy, Sana'a University
Abstract
       The synthesis of N– [5– Methyl– 2– (1, 3, 4 COX-2 selective inhibitor and the preliminary kinetic study for hydrolysis of this compound is studied in this paper. The compound was prepared from the corresponding aspirin and 2–amino–5–methyl–1,3,4–thiadiazole in the presence of N,N-dicyclohexylcarbodiimide (DCC) as coupling agent .
       The preliminary kinetic study for hydrolysis of this compound and the effect of pH on the rate of hydrolysis in buffer solution citrate–phosphate–borate/HCl was studied. The structure was confirmed by infrared, nuclear magnetic resonance (H–NMR), and elemental microanalysis assay. The compound underwent slightly hydrolysis at low and high pH with a fairly stabile so, provide a chance for it to be absorbed intact with highly bioavailability, longer half life, and with lower G1 toxicity.
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