EVALUATION OF ALPHA-GLUTATHIONE-S-TRANSFERASE AS A MARKER OF HEPATOCELLULAR DAMAGE | ||||
| Biochemistry Letters | ||||
| Article 2, Volume 4, Issue 1, 2008, Page 15-40 PDF (410.81 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/blj.2008.64446 | ||||
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| Authors | ||||
| Osman, H. Gh.1; Shiha, G. E2; El-Deeb, K.A.3 | ||||
| 1Faculty of Science, Mansoura University. | ||||
| 2Faculty of Medicine, Mansoura University | ||||
| 3Faculty of Science, Mansoura University | ||||
| Abstract | ||||
| Alpha-glutathione-S-transferase (a-GST) are the cytoplasmatic class of enzymes responsible for cellular detoxifying processes. The serum a-GST activity in relation to chronic infection caused by hepatitis C virus (HCV) and acute infection caused by hepatitis A, B and C viruses. 15 anti-HCV negative and negative for HBV and HAV healthy subjects served (controls), 35 patients with chronic hepatitis [8/35 are anti-HCV positive subjects with normal alanine aminotransferases (ALT) and 27/35 chronic hepatitis are with high ALT levels]; 17 patients with acute liver disease (1 acute HCV infection, 3 acute HBV infections and 13 acute HAV infections were studied. Serum (a-GST) alpha glutathione-S-transferase, (aspartate aminotransferase, alkaline phosphatase (ALP), gamma glutamyl transferase GGT, total protein, albumin, total and direct bilirubin were assayed in all subjects, and after 0 week, 2 weeks and 4 weeks in the acute group. | ||||
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