PHYTOCHEMICAL AND BIOLOGICAL STUDY OF VANGUERIA EDULIS CULTIVATED IN EGYPT | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 6, Volume 35, Issue 1, June 2012, Page 67-81 PDF (339.96 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2012.64603 | ||||
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| Authors | ||||
| Daoud W. Bishay; Enaam Y. Backheet; Yaser Gouda* ; Shaymaa M. Mostafa | ||||
| Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt | ||||
| Abstract | ||||
| Fractionation and purification of the alcoholic extract of the leaves and stem -bark of Vangueria edulis cultivated in Egypt afforded thirteen compounds identified as: β-sitosterol acetate (1), stigmasterol (2), palmitic acid (3), scopoletin (4), p-coumaric acid (5), protocatechuic acid (6), esculetin (7), ethyl 1-O-glucosyl-4-O-(E) caffeoyl quinate (8), kaempferol 3-O-rhamnoside, 7-O-rutinoside (9), β-sitosterol (10), ceryl alcohol (11), vanillic acid (12) and β-sitosterol-3-O-β-D-glucopyranoside (13). Identification of these compounds has been established by physical, chemical and spectral data as well as comparison with authentic samples. Compounds 8 and 9 are firstly reported from a natural source while the rest of the compounds have been isolated for the first time from the genus Vangueria. The LD50, antibacterial, antifungal, anti-inflammatory, antipyretic and the effect on CNS were studied. | ||||
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