Platelet Rich Plasma in Repeated Implantation Failure in Women with Thin Endometrium Thickness
El Hamedi, M., Salem, H. (2019). Platelet Rich Plasma in Repeated Implantation Failure in Women with Thin Endometrium Thickness. EKB Journal Management System, 77(6), 5873-5875. doi: 10.21608/ejhm.2019.64633
Mahmoud A. El Hamedi; Hesham A. Salem. "Platelet Rich Plasma in Repeated Implantation Failure in Women with Thin Endometrium Thickness". EKB Journal Management System, 77, 6, 2019, 5873-5875. doi: 10.21608/ejhm.2019.64633
El Hamedi, M., Salem, H. (2019). 'Platelet Rich Plasma in Repeated Implantation Failure in Women with Thin Endometrium Thickness', EKB Journal Management System, 77(6), pp. 5873-5875. doi: 10.21608/ejhm.2019.64633
El Hamedi, M., Salem, H. Platelet Rich Plasma in Repeated Implantation Failure in Women with Thin Endometrium Thickness. EKB Journal Management System, 2019; 77(6): 5873-5875. doi: 10.21608/ejhm.2019.64633

Platelet Rich Plasma in Repeated Implantation Failure in Women with Thin Endometrium Thickness

The Egyptian Journal of Hospital Medicine
Article 15, Volume 77, Issue 6, October 2019, Page 5873-5875  XML PDF (216.82 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.64633
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Authors
Mahmoud A. El Hamedi1; Hesham A. Salem email 2
1Department of Obstetrics and Gynecology Faculty of Medicine, Zawia University, Libya
2Department of Obstetrics and Gynecology Faculty of Medicine, Tanta University, Egypt
Abstract
Background: repeated implantation failure (RIF) is a major challenge in reproductive medicine. Platelet rich plasma (PRP) was able to promote the endometrial growth and improve pregnancy outcome of patients with thin endometrium. Aim of the study: it was to evaluate the effectiveness of intrauterine infusion of PRP in treatment of thin endometrium in frozen-thawed embryo (FTE) transfer. Patients and Methods: the study included 10 infertile patients with thin endometrium (<7mm) in Frozen Embryo Transfer (FET) program. Estradiol valerate 12 mg/d was started on day 3 of menstrual cycle. PRP was prepared from autologous blood and infused into the uterine cavity. Endometrial thickness was re-assessed and if the endometrial thickness wasn’t satisfactory infusion of PRP was repeated 2-4 times. Cleavage stage embryos were transferred on the 3 rd day after progesterone administration, and blastocysts were transferred on the 5th day after progesterone administration. Results: the endometrial thickness increased after PRP infusion in all the patients, and reached >7mm on the day of progesterone administration. Sixty percent of the patients became pregnant; 83.3% continued pregnancy and 16.7% experienced missed abortion. Conclusion: intrauterine PRP may be effective in promoting endometrial growth, endometrial thickness, and improving pregnancy out come in repeated implantation failure.
Keywords
platelet rich plasma; Repeated; Implantation Failure; Endometrial Thickness
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