COMPATIBILITY AND STABILITY OF TERNARY ADMIXTURE OF MIDAZOLAM, DOBUTAMINE AND DOPAMINE IN 5% GLUCOSE OR 0.9% SODIUM CHLORIDE SOLUTION
El-Sayed, A., Abd El-Mohsen, M., Mohamed, M., Rafat, N., Sayed, O. (2012). COMPATIBILITY AND STABILITY OF TERNARY ADMIXTURE OF MIDAZOLAM, DOBUTAMINE AND DOPAMINE IN 5% GLUCOSE OR 0.9% SODIUM CHLORIDE SOLUTION. EKB Journal Management System, 35(2), 161-180. doi: 10.21608/bfsa.2012.64877
Ahmed M. El-Sayed; Mohamed G. Abd El-Mohsen; Mohamed F. Mohamed; Nafisa H. Rafat; Ola A. Sayed. "COMPATIBILITY AND STABILITY OF TERNARY ADMIXTURE OF MIDAZOLAM, DOBUTAMINE AND DOPAMINE IN 5% GLUCOSE OR 0.9% SODIUM CHLORIDE SOLUTION". EKB Journal Management System, 35, 2, 2012, 161-180. doi: 10.21608/bfsa.2012.64877
El-Sayed, A., Abd El-Mohsen, M., Mohamed, M., Rafat, N., Sayed, O. (2012). 'COMPATIBILITY AND STABILITY OF TERNARY ADMIXTURE OF MIDAZOLAM, DOBUTAMINE AND DOPAMINE IN 5% GLUCOSE OR 0.9% SODIUM CHLORIDE SOLUTION', EKB Journal Management System, 35(2), pp. 161-180. doi: 10.21608/bfsa.2012.64877
El-Sayed, A., Abd El-Mohsen, M., Mohamed, M., Rafat, N., Sayed, O. COMPATIBILITY AND STABILITY OF TERNARY ADMIXTURE OF MIDAZOLAM, DOBUTAMINE AND DOPAMINE IN 5% GLUCOSE OR 0.9% SODIUM CHLORIDE SOLUTION. EKB Journal Management System, 2012; 35(2): 161-180. doi: 10.21608/bfsa.2012.64877

COMPATIBILITY AND STABILITY OF TERNARY ADMIXTURE OF MIDAZOLAM, DOBUTAMINE AND DOPAMINE IN 5% GLUCOSE OR 0.9% SODIUM CHLORIDE SOLUTION

Bulletin of Pharmaceutical Sciences Assiut University
Article 4, Volume 35, Issue 2, December 2012, Page 161-180  XML PDF (1.06 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2012.64877
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Authors
Ahmed M. El-Sayed1; Mohamed G. Abd El-Mohsen1; Mohamed F. Mohamed1; Nafisa H. Rafat2; Ola A. Sayed* 3
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assuit, Egypt
2Department of Pediatrics, Faculty of Medicine, Assiut University, Assuit, Egypt
3El-Azhar University Hospital, Azhar University, Assuit, Egypt
Abstract
The aim of this study was to evaluate compatibility and stability of the maximum concentration used for ternary admixture containing midazolam, dobutamine and dopamine in 5% glucose and 0.9% sodium chloride solutions. The maximum concentration of each drug was 0.144 mg/ml of midazolam, 5.76 mg/ml of dobutamine and 2.88 mg/ml of dopamine in 50 ml of 5% glucose or 0.9% sodium chloride solutions. The physical compatibility of ternary admixtures was assessed using visual inspection and pH determination of ternary admixtures immediately after preparation (at 0 time) and after 24 hrs. The chemical stability was assessed using high performance thin layer chromatoghraphy (HPTLC). The method is based on HPTLC separation of the three drugs followed by densitometric measurements of their spots at 254 nm using Camag TLC Scanner 3. The mobile phase comprised ethyl acetate : n-propanol : water : glecial acetic acid (60:24:9:3, v/v/v/v). There were no visual changes (such as precipitation, gas evaluation or change in color) during 24 hrs after preparation of admixture. Also, there was no change in pH values of admixtures during that time. The results revealed chemical stability of midazolam, dobutamine and dopamine over the duration of mixing (24 hrs) in 5% glucose or 0.9% sodium chloride solutions
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