SYNTHESIS OF SOME THIAZOLIDINE DERIVATIVES OF 1,4-BENZOQUINONE AS POTENTIAL ANTIMICROBIAL AGENTS
Chaaban, I., Bekhit, A., Aboulmagd, E. (2005). SYNTHESIS OF SOME THIAZOLIDINE DERIVATIVES OF 1,4-BENZOQUINONE AS POTENTIAL ANTIMICROBIAL AGENTS. EKB Journal Management System, 28(1), 1-7. doi: 10.21608/bfsa.2005.64882
I. Chaaban; A. A. Bekhit; Elsayed Aboulmagd. "SYNTHESIS OF SOME THIAZOLIDINE DERIVATIVES OF 1,4-BENZOQUINONE AS POTENTIAL ANTIMICROBIAL AGENTS". EKB Journal Management System, 28, 1, 2005, 1-7. doi: 10.21608/bfsa.2005.64882
Chaaban, I., Bekhit, A., Aboulmagd, E. (2005). 'SYNTHESIS OF SOME THIAZOLIDINE DERIVATIVES OF 1,4-BENZOQUINONE AS POTENTIAL ANTIMICROBIAL AGENTS', EKB Journal Management System, 28(1), pp. 1-7. doi: 10.21608/bfsa.2005.64882
Chaaban, I., Bekhit, A., Aboulmagd, E. SYNTHESIS OF SOME THIAZOLIDINE DERIVATIVES OF 1,4-BENZOQUINONE AS POTENTIAL ANTIMICROBIAL AGENTS. EKB Journal Management System, 2005; 28(1): 1-7. doi: 10.21608/bfsa.2005.64882

SYNTHESIS OF SOME THIAZOLIDINE DERIVATIVES OF 1,4-BENZOQUINONE AS POTENTIAL ANTIMICROBIAL AGENTS

Bulletin of Pharmaceutical Sciences Assiut University
Article 1, Volume 28, Issue 1, June 2005, Page 1-7  XML PDF (161.05 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2005.64882
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Authors
I. Chaaban1; A. A. Bekhit1; Elsayed Aboulmagd2
1Department of Pharmaceutical Chemistry
2Department of Microbiology, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt
Abstract
A series of 2,5-disubstituted-1,4-benzoquinone derivatives were synthesized and evaluated for their antimicrobial activity. Coupling of 2,5-dihydroxybenzoic acid (gentisic acid) with the selected thiazolidine derivative using EDC and HOBt afforded the corresponding (4R)-3-(2,5dihydroxybenzoyl)-5,5-dimethyl-N-substituted benzylthiazolidine-4-carboxamide 2a-d. These compounds were subsequently oxidized with ferric chloride to afford the corresponding 1,4benzoquinones 3a-d. The reaction between 1,4-benzoquinone derivatives and the appropriate amine resulted in the targeted 2,5-disubstituted-1,4-benzoquinone derivatives 4a-l. The structure of the newly synthesized compound were confirmed by elemental microanalyses, IR and 1H NMR spectra. The antimicrobial activity of target compounds 4a-l was performed against Escherichia coli (E. coli) ATCC 25922 as Gram-negative bacteria, Staphylococcus aureus (S. aureus) ATCC 19433 as Gram-positive bacteria and Candida albicans (C. albicans) as yeast like fungi were determined
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