Has Resveratrol a Modulatory Effect on Renal Injury Associating Diabetic Nephropathy in Albino Rats? | ||||
| The Medical Journal of Cairo University | ||||
| Article 53, Volume 87, September, September 2019, Page 3163-3174 PDF (1.35 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2019.64898 | ||||
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| Authors | ||||
| NERMEEN B. SADEK, M.D.; MOHAMED A. ESHRА, M.D.; EFFAT A. KHOWAILED, M.D.; LAILA A. RASHED, M.D.; ВАSМА E. ABOULHODA, M.D. | ||||
| The Departments of Physiology*, Biochemistry** and Anatomy, Faculty of Medicine, Cairo University, Egypt | ||||
| Abstract | ||||
| Abstract Background: The involvement of abnormally stimulated renin angiotensin system, excessive formation of reactive oxygen species, increased glucose metabolite flux and up-regulation of pro-inflammatory and profibrotic cytokines in the pathogenesis of diabetic nephropathy has become an emerging concern. Exploration of novel therapies that specif-ically target such factors is a major goal in diabetes treatment. Aim of Study: Our aim is to explore the potential protective and therapeutic effect of resveratrol on DN progression through its antioxidant, anti-inflammatory and antifibrotic role in comparison with losartan as one of the therapeutic regimens used in diabetic nephropathy. Material and Methods: Forty eight male albino rats were assigned into six groups; control, diabetic nephropathy, pro-phylactic losartan, prophylactic resveratrol, therapeutic losartan and therapeutic resveratrol. Systolіc blood pressure, fasting glucose, glomerular filtration rate, urea, urea albumin excretion, tumor necrosis factor a, tansforming growth factor-(3, inter-leukin-б and superoxide dismutase have been measured. Histopathological assessment of inflammation, glomeruloscle-rosis and fibrosis using hematoxylin and eosin, Masson's trichrome and Periodic acid shift staining and histomorpho-metric analysis for glomerular and tubular parameters have also been performed. Results: Prophylactic resveratrol showed significant regression in inflammation, fibrosis and oxidative stress compared with its therapeutic effect. Conclusion: Resveratrol showed better outcome compared with losartan with significant change in the biochemical parameters. | ||||
| Keywords | ||||
| diabetic nephropathy; Resveratrol; Losartan; Inflammation; Oxidative Stress; fibrosis | ||||
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