MRI Evaluation of Hepatic Iron Overload in b-Thalassemic Children | ||||
| The Medical Journal of Cairo University | ||||
| Article 138, Volume 86, December, December 2018, Page 4537-4545 PDF (689.86 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2018.64907 | ||||
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| Authors | ||||
| ALI E.A. AGALN, M.Sc.; MOHAMED A. MOHAMED, M.D.; EBRAHIM M. BADRAIA, M.D.; ABD EL-MONEM N. DARWISH, M.D. | ||||
| The Departments of Diagnostic Radiology* and Pediatrics**, Faculty of Medicine, Tanta University | ||||
| Abstract | ||||
| Abstract Background: b-Thalassaemia major is a hereditary hemo-lytic anemia that have amajor complication iron overload. Assessment of Liver Iron Concentration (LIC) is necessary for detection and quantitative staging of iron overload and monitoring of iron-reducing treatments. MRI represents the most available noninvasive technique to assess LIC. The aim of this study was to assess LIC by MRI in multitransfused b-Thalassemic children. Patients and Methods: Forty multi-transfused b-thalassemic children were subjected to clinical evaluation, appropriate laboratory assessment and assessment of LIC by MRI. T2* weighted gradient echosequence MRI was performed with 1.5T scanner. Results: - Significant reduction in signal intensity ratio of the liver was show in all patients. - Highly significant correlation between MRI parameter (R2* and T2*) and LIC (p<0.001). - Moderate significant correlation between MRI parameters (R2*, T2*) and SF level when serum Ferrittin below 4000 ng/dl and non-significant when SF above 4000ng/dl (p>0.05). - Splenectomizied patients had significant lower SIR of liver (decrease R2* and increase T2*) compared to non splenec-tomized patients (p<0.007). Conclusion: In conclusion based on results of our study MRI is the best noninvasive method for assessment and evaluation of hepatic iron overload and determine its severity in multi-transfused b-thalassemic patients. | ||||
| Keywords | ||||
| Thalassemic children – Hepatic iron overload – MRI | ||||
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