The Protective Effect of Propolis Compared to Vitamins C and E Antioxidant Mixture in Cyclophosphamide-Induced Lung Toxicity In Mice | ||||
| The Medical Journal of Cairo University | ||||
| Article 144, Volume 86, December, December 2018, Page 4585-4593 PDF (654.09 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2018.64913 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| ABDULRAHMAN HAMDAN ALMAEEN, F.K.S.U.; MAHROUS ABD EL-BASSET IBRAHIM, M.D. | ||||
| Abstract | ||||
| Abstract Background: Pulmonary toxicity could be induced by oxidative stress secondary to use of the anti-cancerous agent cyclophosphamide (CTX). Aim of Study: This study was conducted to examine the ameliorating effects of propolis or Vitamins C +Vitamin E antioxidant mixture (Vit. E-C) on lung tissues in mice exposed to cyclophosphamide. Material and Methods: Forty-eight mice were divided into six groups; the first three groups served as control groups and orally received saline, propolis or antioxidant mixture, respectively; group 4 was intraperitoneally (i.p.) injected with a single dose of CTX (200mg/kg); group 5 was injected with a single dose of CTX (200mg/kg) preceded by propolis (90 mg/kg) and group 6 was injected with a single dose of CTX (200mg/kg) preceded by VitE-C antioxidant mixture (50mg/kg bw each) for 14 consecutive days. One day after CTX injection, mice were sacrificed to analyze oxidative stress biomarkers and to examine the histopathological changes. Results: CTX-treated mice developed elevated malondi-aldehyde and declined antioxidant enzymes. Marked patho-logical changes in the lung architectures were observed. Mice treated with CTX/propolis in group 5 and CTX/antioxidant mixture in group 6 showed improvements in the levels of all oxidative stress markers towards normal. This accompanied by significant restoration of normal lung histology. Conclusions: Propolis and Vit. E-C antioxidant mixture showed a promising ameliorative effect on CTX-induced toxicity in mice. | ||||
| Keywords | ||||
| Cyclophosphamide – Propolis – Lung toxicity – Vitamin C – Vitamin E– Oxidative stress | ||||
|
Statistics Article View: 323 PDF Download: 289 |
||||
