NOVEL 1,2,4-TRIAZOLE-3-MERCAPTOACETIC ACID DERIVATIVES AS POTENTIAL ANTIMYCOBACTERIAL AND ANTIMICROBIAL AGENTS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 9, Volume 29, Issue 1, 2006, Page 127-136 PDF (183.66 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2006.65187 | ||||
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| Authors | ||||
| Nawal A. El-Koussi; Hamdy M. Abdel-Rahman | ||||
| Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt | ||||
| Abstract | ||||
| Novel Schiff bases of 4-methyl-1,2,4-triazole-3-mercaptoacetic acid hydrazide were synthesized. Their chemical identities were elucidated by elemental analyses, IR, 1H-NMR, 13C-NMR and mass spectral data. The percentage of the geometrical isomers was also elucidated using the 1H-NMR. The synthesized compounds were selected for screening at the Tuberculosis Antimicrobial Acquisition and Coordination Facility (TAACF) against Mycobacterium tuberculosis H37Rv strain in which they showed moderate activity at a concentration of 6.25 g/ml. Moreover, antimicrobial screenings against E. coli (ATCC 25922), S. aureus (ATCC 19433) and C. albicans identified compound 4g as the most effective showing similar antibacterial activity as ampicillin against S. aureus. | ||||
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