EFFECT OF POROUS SILICA AS A DRUG CARRIER ON THE RELEASE RATE OF NAPROXEN FROM EMULGEL | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 1, Volume 29, Issue 2, December 2006, Page 224-235 PDF (315.48 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2006.65196 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Ahmed Ismail; K. I. Saleh* ; M. A. Ibrahim; S. Khalaf | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt | ||||
| Abstract | ||||
| Naproxen was loaded on Florite R (porous silica) by solvent deposition technique. The physical and loaded drug mixtures were examined by x-ray diffractometry and differential scanning calorimetry (DSC). The in-vitro dissolution of the drug from loaded and physical mixture was studied. The best formula which contains (1:2) drug:adsorbent ratio was formulated into emulgel using different gelling agents. The in-vitro release of naproxen from the selected emulgel bases was carried out. X-ray and DSC results revealed that the drug was changed from the crystalline to amorphous state depending on drug to carrier ratio since the complete transformation was obtained from the loaded mixture containing (1:2) drug:Florite R ratio. Transformation of the drug to the amorphous state in the loaded mixture led to an enhancement of both drug dissolution and in-vitro release rates. | ||||
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