PROPRANOLOL HYDROCHLORIDE-SELECTIVE MEMBRANE ELECTRODE AND THEIR APPLICATION TO PHARMACEUTICAL PREPARATIONS AND BIOLOGICAL FLUIDS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 15, Volume 29, Issue 2, December 2006, Page 488-500 PDF (0 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2006.65228 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Maha El-Tohamy; Magda El-Maamly; Abdalla Shalaby* | ||||
| Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||||
| Abstract | ||||
| The sensitivity and selectivity of a propranolol-selective membrane electrode have been improved with the use of propranolol-ammonium reineckate as electroactive material in the presence of di-butyl sebacate as plasticizer and tetrahydrofuran as solvent mediator. The electrode exhibited a near-Nernstain response over a concentration range of 1x10-2-5x10-6M propranolol hydrochloride with a slope of 52.7±0.6 mV per decade. The practical pH range was 3-8. Interferences from common cations, alkaloids and drug excipients were reported. The proposed electrode has been successfully applied to determine propranolol hydrochloride in pure form and pharmaceutical preparations. The results were correlated well with those obtained by BP standard procedure. | ||||
|
Statistics Article View: 81 PDF Download: 101 |
||||
