SYNTHESIS OF SOME QUINOLINE THIOSEMICARBAZONE DERIVATIVES OF POTENTIAL ANTIMICROBIAL ACTIVITY
Abdel-Moty, S., Abdel-Rahman, M., Elsherief, H., Kafafy, A. (2005). SYNTHESIS OF SOME QUINOLINE THIOSEMICARBAZONE DERIVATIVES OF POTENTIAL ANTIMICROBIAL ACTIVITY. EKB Journal Management System, 28(1), 79-93. doi: 10.21608/bfsa.2005.65235
Samia G. Abdel-Moty; Mostafa H. Abdel-Rahman; Hosney A. Elsherief; Abdel-Hamid N. Kafafy. "SYNTHESIS OF SOME QUINOLINE THIOSEMICARBAZONE DERIVATIVES OF POTENTIAL ANTIMICROBIAL ACTIVITY". EKB Journal Management System, 28, 1, 2005, 79-93. doi: 10.21608/bfsa.2005.65235
Abdel-Moty, S., Abdel-Rahman, M., Elsherief, H., Kafafy, A. (2005). 'SYNTHESIS OF SOME QUINOLINE THIOSEMICARBAZONE DERIVATIVES OF POTENTIAL ANTIMICROBIAL ACTIVITY', EKB Journal Management System, 28(1), pp. 79-93. doi: 10.21608/bfsa.2005.65235
Abdel-Moty, S., Abdel-Rahman, M., Elsherief, H., Kafafy, A. SYNTHESIS OF SOME QUINOLINE THIOSEMICARBAZONE DERIVATIVES OF POTENTIAL ANTIMICROBIAL ACTIVITY. EKB Journal Management System, 2005; 28(1): 79-93. doi: 10.21608/bfsa.2005.65235

SYNTHESIS OF SOME QUINOLINE THIOSEMICARBAZONE DERIVATIVES OF POTENTIAL ANTIMICROBIAL ACTIVITY

Bulletin of Pharmaceutical Sciences Assiut University
Article 10, Volume 28, Issue 1, June 2005, Page 79-93  XML PDF (379.45 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2005.65235
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Authors
Samia G. Abdel-Moty* 1; Mostafa H. Abdel-Rahman2; Hosney A. Elsherief2; Abdel-Hamid N. Kafafy1
1Department of Pharmaceutical Organic Chemistry, Faculty of pharmacy, Assiut University, Assiut-71527, Egypt
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
Abstract
5-Acetyl (or 5-benzoyl)-8-hydroxyquinoline-4-substituted thiosemi- carbazones (IIa-m, IIIa-m respectively) have been prepared via the condensation of 5-acetyl (or 5-benzoyl)-8hydroxyquinoline with the appropriate 4-substituted-3-thiosemicabazides (Ia-l). The thiosemicarbazones (IIa-l, IIIa-f) were subjected to cyclization into the corresponding thiazolidinones (IVa-l, Va-f) by the reaction with ethyl bromoacetate in the presence of anhydrous sodium acetate. The structures of the thiosemicarbazones as well as the corresponding thiazolidinones were assigned based on both elemental and spectroscopic evidences. The prepared compounds were also evaluated for antibacterial and antifungal activities.
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