Design, Synthesis and Antibacterial Study of New Agents Having 4-Thiazolidinone Pharmacophore | ||
| Egyptian Journal of Chemistry | ||
| Article 15, Volume 63, Issue 7, July 2020, Pages 2591-2603 PDF (3.66 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2019.17518.2088 | ||
| Authors | ||
| sarah sedqi ismaeel* 1; Monther F. Mahdi2; Basma M. Abd Razik3 | ||
| 1College of pharmacy, university of Mosul, Mosul, Iraq. | ||
| 2Dean of pharmacy, Al-Mustansiriyah University, Baghdad, Iraq | ||
| 3College of Pharmacy, Al-Mustansiriyah University, 10001, Baghdad | ||
| Abstract | ||
| A new series of compounds containing 4-thiazolidinone pharmacophore 5(a-d) have been synthesized. The chemical structure of the intermediate and final compounds was characterized and confirmed by using FT-IR and 1H-NMR spectroscopy. All final compounds were tested against Gram-positive and Gram-negative bacteria using a well-diffusion technique for their ability as antimicrobial agents. The 5b and 5c compounds tested showed comparable antibacterial activity against Gram-negative bacteria and Gram-positive bacteria, such as Escherichia coli, Acinetobacter bumannii, Staphylococcus aureus, and Streptococcus pyougenes, as a standard drug compared to Trimethoprim. Simulations of the molecular docking of the molecular core were studied. The results have come from an in vitro-based docking of the most active compounds into the active protein site of the bacteria. | ||
| Keywords | ||
| trimethoprim; thiazolidinone; Heterocycles; Antibacterial; and Molecular docking simulations | ||
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