SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANALGESIC AND ANTI-INFLAMMATORY EFFECTS | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 10, Volume 28, Issue 2, December 2005, Page 237-253 PDF (371.6 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.2005.65398 | ||||
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Authors | ||||
H. H. M. Abdu-Allah; S. G. Abdel-Moty; A. A. El-Shorbagi; A. M. Abdel-Alim* | ||||
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut-71526, Egypt | ||||
Abstract | ||||
3-N-(4`-Hydroxy-3`-substituted phenyl)carbamoyl-1-methylpyridinium iodides (compds. 5b-j) and 3-carbamoyl-1-(N-(4`-hydroxy- 3`-substituted phenyl)carbamoyl) methyl pyridinium chlorides (compds. 7a-j) were synthesised and some of them were tested for their analgesic and antiinflammatory activities by hot plate test and carageenin-induced hind paw edema model, respectively. Compound 5b revealed the most potent analgesic and anti-inflammatory activities in comparison to sulfasalazine (SASP) and 5-ASA. In addition, ulcerogenicity, LD50, in-vivo and in vitro cleavage and pH stability of compound 5b were also determined. | ||||
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