COMPATIBILITY STUDY OF FAMOTIDINE WITH SOME PHARMACEUTICAL EXCIPIENTS USING DIFFERENT TECHNIQUES | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 9, Volume 27, Issue 2, December 2004, Page 281-291 PDF (737.53 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2004.65454 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| A. S. Ali Ibrahim; M. Hassan* ; M. G. Abd El-Mohsen; S. M. El-Shanawany | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Famotidine is a member of H2-receptor antagonist drug, which pharmacological action primarily involves antagonism of the action of histamine at its H2-receptors. The incompatibility between famotidine and some commonly used tablet excipients was studied. The investigation was made on Avicel PH 105, Emcocel 90, starch 1500 (Sta-Rx 1500), Emdex, sorbitol, mannitol, cross linked sodium carboxymethylcellulose (Ac-Di-sol), PEG6000, hydroxyethylcellulose (HEC) (natrosol) and saccharin sodium. The investigation is made by DSC, IR and X-ray diffraction analysis. The DSC analysis indicated that there was no interaction between famotidine with Emcocel 90, Avicel PH 105, starch 1500, Ac-Di-sol, mannitol, HEC (natrosol) and saccharin sodium. On the other hand DSC indicated an incompatibility between famotidine and sorbitol, Emdex and PEG6000. The study of IR indicated the interaction between famotidine and PEG6000. X-ray diffraction study was carried out on excipients that showed possible interaction with famotidine during the DSC investigations. Only interaction between famotidine, Emdex and PEG6000 was confirmed. | ||||
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