ADSORPTION OF PARACETAMOL ON ACTIVATED CHARCOAL | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 13, Volume 27, Issue 2, December 2004, Page 325-330 PDF (191.8 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2004.65460 | ||||
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| Authors | ||||
| Syed Saeed-ul- Hassan* 1; Khalid Hussain1; Syed Atif Raza2; Nisar- ur- Rehman3 | ||||
| 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Punjab University, Allama Iqbal Campus, Lahore-54000, Pakistan | ||||
| 2Department of Pharmaceutic, Faculty of Pharmacy, Punjab University, Allama Iqbal Campus, Lahore-54000, Pakistan | ||||
| 3Department of Pharmacy, Islamia University, Bahawalpur, Pakistan | ||||
| Abstract | ||||
| In Vitro studies were carried out to investigate the adsorption activity of activated charcoal for paracetamol powder and tablets at pH 7.5. The effect of alcohol 6% (v/v) and methionine 0.1 (M) on the adsorption activity of activated charcoal for paracetamol was also investigated at pH 7.5 using charcoal to drug ratios as 4:1, 5:1, 6:1, 8:1, 10:1. The adsorption of paracetamol is fast and is 95.6% in 30 minutes. There was no effect on adsorption due to presence of alcohol 6% while methionine 0.1M has little effect on the adsorption of paracetamol as methionine competes for binding sites. It is concluded that activated charcoal is effective in adsorbing paracetamol. Methionine (sulphydryl) compound can be used as an antidote along with activated charcoal because of its negligible effect on adsorption of paracetamol. | ||||
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