UTILIZATION OF PLANTAGO, PECTIN AND COMPRITOL FOR THE PRODUCTION OF SUSTAINED RELEASE TRAMADOL MATRIX TABLETS BY DIRECT COMPRESSION | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 3, Volume 26, Issue 2, December 2003, Page 119-136 PDF (847.13 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2003.65477 | ||||
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| Authors | ||||
| Adel M. Aly; Sara A.M. Aly; Raslan H. M. Kittaneh | ||||
| College of Pharmacy, Alisra University, Amman, Jordan | ||||
| Abstract | ||||
| Tramadol is an opioid analgesic. It is indicated for the relief of moderate to moderately sever pain across the full range of acute and chronic pain syndromes. Due to its short half-life (5 to 7 hours) and its short duration of action (3 to 7 hours), it was highly desirable to slow the rate of absorption of tramadol and spread the absorption process over a longer interval, with increasing patient compliance and decreasing the risk and severity of adverse effects. Consequently, sustained release tramadol tablets were prepared utilizing the following materials: Compritol (CT), Plantago (PT), Pectin (PC), and HPMC. The inclusion of HPMC with CT, prolongs the release of tramadol more than CT alone. Also, by increasing HPMC concentration more sustaining effect could be obtained, but at 15% less sustaining effect was observed. The inclusion of NaAlg retards the release more than NaCMC, either with or without Avicel. PC showed pronounced sustaining effect with NaAlg alone (either with or without Avicel) compared to those containing NaCMC alone or with NaAlg. However, in case of tablets containing PT; the inclusion of NaCMC, either alone or in combination with NaAlg, retards the release of drug more than NaAlg alone. Aiming for more sustaining properties smaller tablets (250 mg) containing the same proportions of CT and HPMC but lower % of Avicel, NaCMC or NaAlg were prepared. Formula containing NaCMC alone showed the most sustaining effect (more than Tramal®) followed by those including NaCMC and Avicel. | ||||
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