IN-VITRO STUDIES ON CORTICOSTERONE PERMEATION THROUGH HAIRLESS MOUSE SKIN: ( PART I) | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 4, Volume 26, Issue 2, December 2003, Page 137-144 PDF (298.86 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.2003.65479 | ||||
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Authors | ||||
Fahima M. Hashem1; Abdel Ghanem2; Eman. S. El-leithy1; Dalia. S. Shaker1 | ||||
1Department. of Pharmaceutics, Faculty of Pharmacy, Helwan University | ||||
2Faculty of Pharmacy, University of Utah, USA | ||||
Abstract | ||||
The use of penetration enhancer adjuvants was emerged as a growing trend in transdermal drug delivery. These adjuvants may reduce the capacity for drug binding to skin and promote the permeation of bimolecules through the skin. The main objective of this study was to evaluate the effect of polyvinylpyrrolidone (PVP) and hydroxypropyl–beta-cyclodextrin (HP- -CD) as well as certain chemical enhancers on solubility of unlabeled corticosterone (CS) and its transdermal permeation through skin. The results revealed that autoclaving CS with PVP maintained supersaturated state through inhibition of crystal growth and in turn increased its flux across hairless mouse skin. The data showed also that HP- -CD had no effect on CS permeation but could be used as solubilizing agent for highly lipophilic skin permeation enhancers octyl pyrrolidone (OP) and dodecyl pyrrolidone (DDP). It also prevented depletion of such lipophilic enhancers into skin, increased by this way the permeation enhancement of these adjuvants | ||||
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