BIOACTIVE PRINCIPLES OF THE FLOWERS OF PANCRATIUM MARITIMUM | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 6, Volume 26, Issue 2, December 2003, Page 171-177 PDF (192.62 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2003.65481 | ||||
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| Author | ||||
| Diaa T.A. Youssef | ||||
| Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt | ||||
| Abstract | ||||
| Bioactive-guided fractionation and purification of the ethyl acetate fraction of an ethanolic extract of fresh flowers of Pancratium maritimum (Amaryllidaceae) cultivated in Egypt yielded an alkaloid, pancratistatin (1), together with 3- caffeoylquinic acid methyl ester (2). Their structures were determined on the basis of extensive 1D (1H and 13C) and 2D (COSY, HMQC, HMBC, and NOESY) NMR studies and high-resolution mass spectral measurements. Both compounds showed potent cytotoxic activity against HeLa cells and moderate anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv. This is the first report of pancratistatin in Pancratium maritimum and the first report of 3-caffeoylquinic acid methyl ester in the family Amaryllidaceae. | ||||
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