Enhancement of dissolution rate of meclozine HCl by co-grinding and loading onto certain adsorbents | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 2, Volume 25, Issue 1, June 2002, Page 7-14 PDF (414.71 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2002.65504 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| A. Aboutaleb; A. Abdel-Rahman; M. Ahmed; U. Abu Uwaida | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Egypt | ||||
| Abstract | ||||
| The aim of this work was to improve the soly. and dissoln. rate of, the sparingly water-sol. drug, meclozine hydrochloride (Mz). Two approaches were utilized namely, solvent deposition onto certain adsorbents and co grinding with these adsorbents. Phys. mixts. of Mz with the investigated adsorbents were also prepd. The used adsorbents were porous silica (Florite), veegum and bentonite. The mol. behavior of Mz in the investigated systems were studied using x-ray diffraction anal. and differential scanning calorimetry (DSC). The DSC results showed that the drug melting peak was reduced in intensity or disappeared totally in the obtained thermograms. This was noticed to be dependent on the adsorbent type as well as the wt. ratio of the drug to the adsorbent in the mixt. The obtained results indicated that Mz was transformed from the cryst. to the amorphous state in both the ground and the loaded mixts. with Florite. This transformation resulted in a significant enhancement in the dissoln. rate of the drug. In addn., it was noticed that the drug: adsorbent wt. ratio of the prepd. mixts. influenced the drug dissoln. rate enhancement. Accordingly, it can be concluded that by increasing the wt. ratio of the used adsorbent in the mixt., the larger the enhancement in the dissoln. rate of Mz was obtained | ||||
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