Neutrophil Gelatinase-Associated Lipocalin as Early Sign of Diabetic Kidney Injury in Children
Mohammed Ali Elsharkawy, M., Amin, E., Eldarawany, Z., Khalifa, N., Basha, M. (2022). Neutrophil Gelatinase-Associated Lipocalin as Early Sign of Diabetic Kidney Injury in Children. EKB Journal Management System, 28(3), 505-511. doi: 10.21608/zumj.2019.18596.1603
Mona Mohammed Mohammed Ali Elsharkawy; Ezzat kamel Amin; Zeinb Esmail Eldarawany; Naglaa Ali Khalifa; Mohammad Abd Alkhalik Basha. "Neutrophil Gelatinase-Associated Lipocalin as Early Sign of Diabetic Kidney Injury in Children". EKB Journal Management System, 28, 3, 2022, 505-511. doi: 10.21608/zumj.2019.18596.1603
Mohammed Ali Elsharkawy, M., Amin, E., Eldarawany, Z., Khalifa, N., Basha, M. (2022). 'Neutrophil Gelatinase-Associated Lipocalin as Early Sign of Diabetic Kidney Injury in Children', EKB Journal Management System, 28(3), pp. 505-511. doi: 10.21608/zumj.2019.18596.1603
Mohammed Ali Elsharkawy, M., Amin, E., Eldarawany, Z., Khalifa, N., Basha, M. Neutrophil Gelatinase-Associated Lipocalin as Early Sign of Diabetic Kidney Injury in Children. EKB Journal Management System, 2022; 28(3): 505-511. doi: 10.21608/zumj.2019.18596.1603

Neutrophil Gelatinase-Associated Lipocalin as Early Sign of Diabetic Kidney Injury in Children

Zagazig University Medical Journal
Article 15, Volume 28, Issue 3, May 2022, Page 505-511  XML PDF (347.68 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.18596.1603
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Authors
Mona Mohammed Mohammed Ali Elsharkawy email 1; Ezzat kamel Amin2; Zeinb Esmail Eldarawany2; Naglaa Ali Khalifa3; Mohammad Abd Alkhalik Bashaorcid 4
1Pediatric Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt
2Department of Pediatric, Faculty of Medicine – Zagazig University, Egypt
3Department of Clinical pathology, Faculty of Medicine – Zagazig University, Egypt
4Department of Radiodiagnosis, Faculty of Medicine – Zagazig University, Egypt
Abstract
Background: Type 1 diabetes mellitus (T1DM), the most common endocrine disorder of childhood, leads to various macro- and microvascular complications. Diabetic nephropathy (DN) is one of the major microvascular complications of T1DM and results in end-stage renal disease (ESRD). Aim of the work: This study is to assess whether urinary NGAL (uNGAL) levels and Doppler ultrasonography can predict the early phases of diabetic kidney injury in childhood Methods: The is a case control study was conducted in pediatrics outpatient clinics at Zagazig University Hospitals on 32 participants, 16 ones of them were a diabetic children at outpatients clinic and matched with 16 healthy subjects. Results: The results of the study revealed that, at cutoff point of 56.4 ng/ml, Urinary NGAL was 100% sensitive, 81.2% specific and 90.6% accurate, that there was a statistical significant difference between the studied groups in Urinary NGAL and Urinary NGAL/Cr ratio. Cases group had significantly higher Urinary NGAL and Urinary NGAL/Cr ratio than control group. Conclusion: NGAL is a rising and promising marker for early detection of DN. It can detect the tubular phase of DN even before the onset of Microalbuminuria.
Keywords
Urinary NGAL; T1DM; diabetic nephropathy; childhood
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