Study of some characteristics of egg-lecithin liposomes prepared by extrusion and freeze-thawing method | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 25, Issue 2, December 2002, Page 175-179 PDF (335.48 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2002.65696 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| M. El-Badry | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Egypt | ||||
| Abstract | ||||
| Liposomes were prepd. by extrusion and freeze-thawing method using carboxyfluorescein as marker. The effect of the no. of extrusion, Freeze-thawing cycles on lipid content, liposome size and encapsulation efficiency was investigated. The results revealed that, there was a direct relationship between the membrane pore size and particle size of liposomes. However, there was an inverse relation between the no. of extrusion cycles and size of liposomes. In the meantime, increasing the no. of extrusion cycles produced homogeneous liposomes. Also an inverse relation was found between the no. of extrusion cycles and encapsulation efficiency of the marker. Freeze-thawing process offered high encapsulation efficiency of carboxyfluorescein inside liposomes. | ||||
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