Phytochemical and pharmacological studies on Pulicaria orientalis Jaub & Sp. | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 9, Volume 25, Issue 2, December 2002, Page 189-200 PDF (782.46 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2002.65699 | ||||
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| Authors | ||||
| Zedan Z. Ibraheim1; Hatem A. Salem2 | ||||
| 1Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Department of Pharmacology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| The alc. ext. of the aerial parts of Pulicaria orientalis Jaub & Sp. (Arabic name Arar) growing in Saudi Arabia and its chloroform and Et acetate fractions were subjected to preliminary hypoglycemic and anti-inflammatory screening. The total alc. ext. and its chloroform and Et acetate fractions showed a significant hypoglycemic effect in normal and glucose-loaded animals and a significant anti-inflammatory activity using formalin-induced edema. From the pharmacol. active chloroform fraction of the total alc. ext. of the dried aerial part of Pulicaria orientalis six flavonoidal compds. were isolated and identified as kaempferol 3,7-di-Me ether, kaempferol 3-Me ether, quercetin-3-Me ether, 2R,3R-dihydrokaempferol, kaempferol and quercetin in addn. to β-sitosterol and β-sitosterol glucoside. Only one major compd. was isolated from the Et acetate fraction and identified as quercetin-3-O-β-D-glucoside. | ||||
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