Determination of critical micelle concentration (CMC) of different pluronics with two different methods
El-Badry, M., Schubert, R. (2002). Determination of critical micelle concentration (CMC) of different pluronics with two different methods. EKB Journal Management System, 25(2), 201-205. doi: 10.21608/bfsa.2002.65701
M. El-Badry; Rolf Schubert. "Determination of critical micelle concentration (CMC) of different pluronics with two different methods". EKB Journal Management System, 25, 2, 2002, 201-205. doi: 10.21608/bfsa.2002.65701
El-Badry, M., Schubert, R. (2002). 'Determination of critical micelle concentration (CMC) of different pluronics with two different methods', EKB Journal Management System, 25(2), pp. 201-205. doi: 10.21608/bfsa.2002.65701
El-Badry, M., Schubert, R. Determination of critical micelle concentration (CMC) of different pluronics with two different methods. EKB Journal Management System, 2002; 25(2): 201-205. doi: 10.21608/bfsa.2002.65701

Determination of critical micelle concentration (CMC) of different pluronics with two different methods

Bulletin of Pharmaceutical Sciences Assiut University
Article 10, Volume 25, Issue 2, December 2002, Page 201-205  XML PDF (284.71 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2002.65701
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Authors
M. El-Badry1; Rolf Schubert2
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Egypt
2Department of Pharmaceutical Technology, Institute of Pharmacy, Freiburg University, Freiburg i.BR., Germany
Abstract
Pluronics are series of closely related block copolymers of ethylene oxide and propylene oxide and are used primarily in pharmaceutical formulation as emulsifying or solubilizing agents.  In this study, the crit. micelle concn. (CMC) of different pluronics such as L61, L62, L63, L64, L92, F38, and F68 was measured by two different methods.  The first method is the surface tension method (ring method)​; the second one is fluorimetrical method by using DPH (1,​6 di-​Ph hexatriene)​.  It was found that, by increasing the lipophilicity of the block copolymer (increase the propylene oxide moiety) the CMC value increases.  Also, the fluorimetric method is very sensitive, accurate and more reproducible than surface tension method.
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