Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic
El-Shorbagi, A., Hayallah, A., Omar, N., Ahmed, A. (2001). Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic. EKB Journal Management System, 24(1), 7-20. doi: 10.21608/bfsa.2001.65750
A. A. El-Shorbagi; A. A. Hayallah; N. M. Omar; A. N. Ahmed. "Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic". EKB Journal Management System, 24, 1, 2001, 7-20. doi: 10.21608/bfsa.2001.65750
El-Shorbagi, A., Hayallah, A., Omar, N., Ahmed, A. (2001). 'Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic', EKB Journal Management System, 24(1), pp. 7-20. doi: 10.21608/bfsa.2001.65750
El-Shorbagi, A., Hayallah, A., Omar, N., Ahmed, A. Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic. EKB Journal Management System, 2001; 24(1): 7-20. doi: 10.21608/bfsa.2001.65750

Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic

Bulletin of Pharmaceutical Sciences Assiut University
Article 2, Volume 24, Issue 1, June 2001, Page 7-20  XML PDF (457.15 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2001.65750
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Authors
A. A. El-Shorbagi; A. A. Hayallah; N. M. Omar; A. N. Ahmed
Department of Pharmaceutial Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71526, Egypt
Abstract
The present work reports on the synthesis and preliminary pharmacol. investigation of new 3-​aryl-​6,​7-​dimethyl-​9-​substituted thiazolo[3,​2-​a]​benzimidazolium salts.  These derivs. were synthesized by reacting the 3-​aryl-​6,​7-​dimethylthiazolo[3,​2-​a]​benzimidazoles with the appropriate quaternizing agent.  The latter compds. were, in turn prepd. by cyclodehydration of 5,​6-​dimethyl-​2-​(phenacylthio)​benzimidazoles in polyphosphoric acid (PPA)​.  The latter derivs. were obtained by the reaction of 5,​6-​dimethylbenzimidazole-​2-​thione with the appropriate phenacyl bromide.  Some of the tested compds. have shown a pronounced hypoglycemic activity.  The results do permit the assignment of compds. having N9-​phenacyl entity as promising antidiabetic agents.
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