PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES
Allam, A., El-Shanawany, M., Backheet, E., Nafady, A. (2014). PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES. EKB Journal Management System, 37(2), 65-76. doi: 10.21608/bfsa.2014.65789
Ahmed E. Allam; Mohamed A. El-Shanawany; Enaam Y. Backheet; Alaa M. Nafady. "PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES". EKB Journal Management System, 37, 2, 2014, 65-76. doi: 10.21608/bfsa.2014.65789
Allam, A., El-Shanawany, M., Backheet, E., Nafady, A. (2014). 'PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES', EKB Journal Management System, 37(2), pp. 65-76. doi: 10.21608/bfsa.2014.65789
Allam, A., El-Shanawany, M., Backheet, E., Nafady, A. PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES. EKB Journal Management System, 2014; 37(2): 65-76. doi: 10.21608/bfsa.2014.65789

PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES

Bulletin of Pharmaceutical Sciences Assiut University
Article 1, Volume 37, Issue 2, December 2014, Page 65-76  XML PDF (798.2 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2014.65789
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Authors
Ahmed E. Allam* 1; Mohamed A. El-Shanawany2; Enaam Y. Backheet2; Alaa M. Nafady1
1Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
2Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
Abstract
Five compounds (1-5) were firstly reported from the genus Centaurium family Gentianaceae. They were identified as Lisianthoside 1, Secoxyloganin 2, Secologanin dimethyl acetal 3, 1,8-Dihydroxy-3,5,6,7-tetramethoxyxanthone (Demethyleustomin) 4 and 1-Hydroxy3,5,6,7,8-pentamethoxyxanthone (Eustomin) 5. Structure elucidation was carried out with support of chemical and spectral analysis including 1D and 2D NMR experiments. All the isolated compounds showed promising antioxidant activity, liver microsomal enzymes reducing activity and CYP3A4 mRNA inhibition activity in the HepG2 cell line.
 
 
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