LEPTIN INTERRELATION BETWEEN ADIPOGENESIS AND ANGIOGENESIS WITH RESPECT TO THE INFLAMMATORY STATUS AND SEVERITY OF THE UNDERLYING NON-ALCOHOLIC FATTY LIVER DISEASES IN OBESE ALBINO RATS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 3, Volume 37, Issue 2, December 2014, Page 91-103 PDF (858.9 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2014.65791 | ||||
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| Authors | ||||
| Maiiada Hassan Nazmy* 1; Manal Ismail Abdel-Ghany2 | ||||
| 1Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61111, Egypt | ||||
| 2Department of Pathology, Faculty of Medicine, Minia University, Minia 61111, Egypt | ||||
| Abstract | ||||
| The present study aims to offer more reliable non-invasive markers for the distinction between pure fatty change and steatohepatitis. Sixty male albino rats, equally divided into 4 groups (15 rats/group). Group I acted as normal control were fed standard diet. Groups II, III, IV were fed high fat diet for 4, 8, 12 weeks respectively. High fat diet caused sustained hyperglycemia, hyperinsulinemia and insulin resistance. It also induced significant histopathological and biochemical changes in liver enzymes, lipid profile and lipid peroxidation. It significantly increased both serum and tissue levels of leptin, vascular endothelial growth factor, tumor necrosis factor- alpha and interleukin-6. All tested parameters were significantly correlated with histological scoring. Suggested parameters, based on their involvement as key players in disease pathogenesis, may be useful as non-invasive diagnostic tools for obesity-related non-alcoholic fatty liver diseases. | ||||
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