Preparation and in-vitro evaluation of oral controlled-release matrix tablets containing diclofenac sodium | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 8, Volume 24, Issue 1, June 2001, Page 55-64 PDF (279.16 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2001.65795 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| F. A. Mohammed; M. A. Hassan; M. Fathy | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Egypt | ||||
| Abstract | ||||
| Controlled-release matrix tablets contg. 100 mg-diclofenac sodium were successfully prepd. using egg albumin and three matrixes forming materials namely, sodium CM-cellulose (NaCMC), hydroxypropylmethyl cellulose (HPMC) and Eudragit RS. The prepd. tablets were evaluated for their phys. parameters and the drug release rate. All the prepd. tablet formulations showed acceptable phys. parameters. The release rate was variable depending on the compn. of the matrix tablet and pH of the dissoln. medium. The release profiles and the release kinetics were compared with two com. available sustained-release tablet formulations of diclofenac sodium, Voltaren SR 100 (Ciba Geigy, USA) and Diclofen SR 100 (The United Pharm. Co., Jordan). The drug release data was fitted to various kinetic models. The drug release from all the tested formulations could be described by the diffusion mechanisms. Tablets prepd. with either egg albumin or combination of egg albumin and NaCMC gave release kinetics that were not significantly different from the com. formulations. Based on exptl. results, prepn. of controlled-release matrix tablets of diclofenac sodium using egg albumin is promising | ||||
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