Granule stress relaxation studies as a function of different lubricants
Ebba, F., Prinderre, P., Omar, S., Piccerelle, P., Opota, D., Reynier, J., Joachim, J. (2001). Granule stress relaxation studies as a function of different lubricants. EKB Journal Management System, 24(2), 105-113. doi: 10.21608/bfsa.2001.65904
F. E. Ebba; P. Prinderre; S. Omar; Ph. Piccerelle; D. O. Opota; J. P. Reynier; J. Joachim. "Granule stress relaxation studies as a function of different lubricants". EKB Journal Management System, 24, 2, 2001, 105-113. doi: 10.21608/bfsa.2001.65904
Ebba, F., Prinderre, P., Omar, S., Piccerelle, P., Opota, D., Reynier, J., Joachim, J. (2001). 'Granule stress relaxation studies as a function of different lubricants', EKB Journal Management System, 24(2), pp. 105-113. doi: 10.21608/bfsa.2001.65904
Ebba, F., Prinderre, P., Omar, S., Piccerelle, P., Opota, D., Reynier, J., Joachim, J. Granule stress relaxation studies as a function of different lubricants. EKB Journal Management System, 2001; 24(2): 105-113. doi: 10.21608/bfsa.2001.65904

Granule stress relaxation studies as a function of different lubricants

Bulletin of Pharmaceutical Sciences Assiut University
Article 1, Volume 24, Issue 2, December 2001, Page 105-113  XML PDF (600.58 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2001.65904
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Authors
F. E. Ebba1; P. Prinderre1; S. Omar2; Ph. Piccerelle1; D. O. Opota1; J. P. Reynier1; J. Joachim1
1Laboratoire de Pharmacie Galenique Industrielle etde Cosmetologie, Faculte de Phannacie, Universite, de la Mediterranee, Marseille-France
2Department of Pharmaceutics, Faculty of Pharmacy, He/wan University, Cairo, Egypt
Abstract
Effect of the visco-​elastic properties of different lubricants, namely magnesium stearate, talc and precirol, on granule compaction properties was examd. using texture analyzer TAXT21.  Stress relaxation curves of the compacts have been discussed in relation with three parameters (porosity, visco-​elasticity as well as particle size)​.  The study revealed that bonding in compacted granules lubricated with magnesium stearate was higher than those in compacts with other lubricants in study.  It is reasonable that, the large stress relaxation due to magnesium stearate was plastic deformation dependent with no evidence of fragmentation.  While, small stress relaxation due to talc or precirol suggested that, these materials deformed principally by fragmentation.  However, magnesium stearate as tablet lubricant, could be characterized by minimizing the accumulation of stress in the compact, which cause problem of capping, leading to the optimization of tablet manufg.
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