PART I: NOVEL QUINOXALINE DERIVATIVES OF BIOLOGICAL INTEREST
Badran, M., Botros, S., El-Gendy, A., Abdou, N., El-Assi, H., Salem, A. (2001). PART I: NOVEL QUINOXALINE DERIVATIVES OF BIOLOGICAL INTEREST. EKB Journal Management System, 24(2), 135-144. doi: 10.21608/bfsa.2001.65967
M. M. Badran; S. Botros; A. A. El-Gendy; N. A. Abdou; H. El-Assi; A. Salem. "PART I: NOVEL QUINOXALINE DERIVATIVES OF BIOLOGICAL INTEREST". EKB Journal Management System, 24, 2, 2001, 135-144. doi: 10.21608/bfsa.2001.65967
Badran, M., Botros, S., El-Gendy, A., Abdou, N., El-Assi, H., Salem, A. (2001). 'PART I: NOVEL QUINOXALINE DERIVATIVES OF BIOLOGICAL INTEREST', EKB Journal Management System, 24(2), pp. 135-144. doi: 10.21608/bfsa.2001.65967
Badran, M., Botros, S., El-Gendy, A., Abdou, N., El-Assi, H., Salem, A. PART I: NOVEL QUINOXALINE DERIVATIVES OF BIOLOGICAL INTEREST. EKB Journal Management System, 2001; 24(2): 135-144. doi: 10.21608/bfsa.2001.65967

PART I: NOVEL QUINOXALINE DERIVATIVES OF BIOLOGICAL INTEREST

Bulletin of Pharmaceutical Sciences Assiut University
Article 15, Volume 24, Issue 2, December 2001, Page 135-144  XML PDF (525.58 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2001.65967
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Authors
M. M. Badran1; S. Botros1; A. A. El-Gendy1; N. A. Abdou1; H. El-Assi1; A. Salem2
1Departments of 'Organic Chemistry
2Pharmacology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
Abstract
2-Substituted amino-Bi-tl-pyrazotyliquinoxalines 4-11 wereprepared by reacting 2-chloro- 3-hydrazinoquinoxaline 1 with 1,3-dicarbonyl compounds followed by treatment of the resulting 2-chloro-3-(1-pyrazolyl)quinoxlines 2,3 with the proper 2 ° amine. Reacting 1 with pyruvic acid or its ethyl ester afforded the corresponding hydrazone. Upon treating the hydrazone 15 with POCl3, the corresponding [1,2 ,4Jtriazino[4 ,3-a] quinoxallne 17 was achieved. Further, a series of 4-(piperazinyl) tetrazolojl ,5-a]quinoxalines 19-24 was prepared by reacting 1 with nitrous acid followed by treatment of the resulting 4-d,lorotetrazolo[l ,5-a]quinoxalines 18 with ]­substituted piperazlnes. Biological testing of some of the prepared compounds revealed that these compounds may have antidepressant activity and compound 4 has the most pronounced effect
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