Biologically active abietane diterpenes from Taxodium distichum seeds | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 1, Volume 22, Issue 1, June 1999, Page 21-25 PDF (137.04 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.1999.65968 | ||||
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Authors | ||||
Amany S. Ahmed,; Nasr A. Ei-Emary | ||||
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
Abstract | ||||
Four diterpenes, taxodone, taxodione, 11-hydroxymontbretol, and ferruginol, were isolated from Taxodium distichum (L.) Rich seeds. Taxodone and taxodione were isolated before from the same source and have been reported to possess antitumor activity. 11-Hydroxymontbretol and ferruginol were isolated for the first time here from the genus Taxodium. The structures of the isolated compds. was detd. through intensive spectral anal. HIV-1 PR inhibitory activity for the four compds. showed that only taxodione had a potent effect in 0.1 mM concn. | ||||
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