Chenopodium Murale Essential Oil Alleviates The Genotoxicity and Oxidative Stress of Silver Nanoparticles in The Rat Kidney
Abdel-Wahhab, M., Ahmed, H., El-Nekeety, A., Abdel-Aziem, S., Shara, H., Abdelaziz, M., Sallam, M., Mannaa, F. (2020). Chenopodium Murale Essential Oil Alleviates The Genotoxicity and Oxidative Stress of Silver Nanoparticles in The Rat Kidney. EKB Journal Management System, 63(7), 2631-2646. doi: 10.21608/ejchem.2019.18341.2128
Mossad Attia Abdel-Wahhab; Helmy M.S Ahmed; Aziza A El-Nekeety; Sekena H Abdel-Aziem; Hafiza A. Shara; Mohamed Abdelaziz; Mohamed F. Sallam; Fathia A. Mannaa. "Chenopodium Murale Essential Oil Alleviates The Genotoxicity and Oxidative Stress of Silver Nanoparticles in The Rat Kidney". EKB Journal Management System, 63, 7, 2020, 2631-2646. doi: 10.21608/ejchem.2019.18341.2128
Abdel-Wahhab, M., Ahmed, H., El-Nekeety, A., Abdel-Aziem, S., Shara, H., Abdelaziz, M., Sallam, M., Mannaa, F. (2020). 'Chenopodium Murale Essential Oil Alleviates The Genotoxicity and Oxidative Stress of Silver Nanoparticles in The Rat Kidney', EKB Journal Management System, 63(7), pp. 2631-2646. doi: 10.21608/ejchem.2019.18341.2128
Abdel-Wahhab, M., Ahmed, H., El-Nekeety, A., Abdel-Aziem, S., Shara, H., Abdelaziz, M., Sallam, M., Mannaa, F. Chenopodium Murale Essential Oil Alleviates The Genotoxicity and Oxidative Stress of Silver Nanoparticles in The Rat Kidney. EKB Journal Management System, 2020; 63(7): 2631-2646. doi: 10.21608/ejchem.2019.18341.2128

Chenopodium Murale Essential Oil Alleviates The Genotoxicity and Oxidative Stress of Silver Nanoparticles in The Rat Kidney

Egyptian Journal of Chemistry
Article 18, Volume 63, Issue 7, July 2020, Page 2631-2646  XML PDF (1.64 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.18341.2128
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Authors
Mossad Attia Abdel-Wahhab email orcid 1; Helmy M.S Ahmed2; Aziza A El-Nekeety3; Sekena H Abdel-Aziem4; Hafiza A. Shara5; Mohamed Abdelazizorcid 6; Mohamed F. Sallam7; Fathia A. Mannaa8
1Department of Food Toxicology & Contaminants. National Research Center
2Department of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University
3Food Toxicology & Contaminants Dept., National Research Center
4Cell Biology Dept, National Research Center
5Pathology Dept., National Research Center
6Microbial Chemistry Dept., National Research Center
7New Kasr Al-Ainy Hospital, Cairo
8Physiology Dept. National Research Center
Abstract
This study aimed to synthesize AgNPs using Chenopodium murale extract (CME), to evaluate the antioxidant activity of the Chenopodium murale essential oil (CMEO) and the protective role against nephrotoxicity of AgNPs. Seven groups of female Sprague-Dawley rats were treated orally for 21 days included the control group, AgNPs-treated groups (25 or 50 mg/kg b.w), CMEO-treated groups (0.5 or 1 mg/kg b.w) and AgNPs plus CMEO-treated groups. The synthesized AgNPs were 30-50 nm in size. CMEO is rich in total phenolic and flavoniods and showed high antioxidant and radicals scavenging activity in vitro. AgNPs disturbed kidney function, decreased the antioxidant enzymes, increased serum electrolytes, TNF-α, MDA and NO, up-regulated Bcl-2, down-regulated Bax and P53 and induced histological changes in kidney tissue. CMEO protected the kidney against AgNPs toxicity in a dose-dependent manner. It could be concluded that AgNPs induced cytotoxicity and oxidative stress in the kidney. CMEO overcomes the nephrotoxicity and should be considered as a supplement to protect the kidney against oxidative stress.
Keywords
Chenopodium murale; silver nanoparticles; Nephrotoxicity; essential oil; Oxidative Stress; genotoxicity
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