Rescue effects of prenatal melatonin administration against bisphenol A- induced perturbations of reproductive and thyroid activities in male rat offsprings
M. A. Hassanin, K., S. Ibrahim, S., Abdel-Wahab, A., M. M. H. EL.Kossi, D., H. Abdel-Razik, A. (2019). Rescue effects of prenatal melatonin administration against bisphenol A- induced perturbations of reproductive and thyroid activities in male rat offsprings. EKB Journal Management System, 26(2), 214-234. doi: 10.21608/jvmr.2019.66110
Kamel M. A. Hassanin; Shawky S. Ibrahim; Ahmed Abdel-Wahab; Dina M. M. H. EL.Kossi; Abdel-Razik H. Abdel-Razik. "Rescue effects of prenatal melatonin administration against bisphenol A- induced perturbations of reproductive and thyroid activities in male rat offsprings". EKB Journal Management System, 26, 2, 2019, 214-234. doi: 10.21608/jvmr.2019.66110
M. A. Hassanin, K., S. Ibrahim, S., Abdel-Wahab, A., M. M. H. EL.Kossi, D., H. Abdel-Razik, A. (2019). 'Rescue effects of prenatal melatonin administration against bisphenol A- induced perturbations of reproductive and thyroid activities in male rat offsprings', EKB Journal Management System, 26(2), pp. 214-234. doi: 10.21608/jvmr.2019.66110
M. A. Hassanin, K., S. Ibrahim, S., Abdel-Wahab, A., M. M. H. EL.Kossi, D., H. Abdel-Razik, A. Rescue effects of prenatal melatonin administration against bisphenol A- induced perturbations of reproductive and thyroid activities in male rat offsprings. EKB Journal Management System, 2019; 26(2): 214-234. doi: 10.21608/jvmr.2019.66110

Rescue effects of prenatal melatonin administration against bisphenol A- induced perturbations of reproductive and thyroid activities in male rat offsprings

Journal of Veterinary Medical Research
Article 6, Volume 26, Issue 2, December 2019, Page 214-234  XML PDF (1.86 MB)
Document Type: Original Article
DOI: 10.21608/jvmr.2019.66110
View on SCiNiTO View on SCiNiTO
Authors
Kamel M. A. Hassanin1; Shawky S. Ibrahim2; Ahmed Abdel-Wahab3; Dina M. M. H. EL.Kossi3; Abdel-Razik H. Abdel-Razik4
11- Biochemistry Department, Faculty of Veterinary Medicine, Minia University, Minia 61519, Egypt
2Physiology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt
3Physiology Department, Faculty of Veterinary Medicine, Minia University, Minia 61519, Egypt
4Histology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt
Abstract
The current study aimed to investigate the effects of prenatal melatonin “MLT” administration against bisphenol A “BPA”- induced infertility and thyroid dysfunction in male rat offsprings (First generation “F1”). For that purpose, fifty adult albino rats (40 females and 10 males) were used and classified equally into five groups (8 females and 2 males in each group). First group (control group) in which, pregnant rats were injected with 0.3 ml of vehicle /day. The second group (low dose BPA) where rats received a daily dose of 25 µg / kg B.W. The third group (high dose BPA) where rats received a daily dose of 250 µg / kg B.W. Fourth group (low dose BPA + MLT) where rats received a daily dose of 25 µg BPA /kg B.W. plus 10 mg MLT / Kg B.W. The fifth group (high dose BPA + MLT) where the rats received a daily dose of 250 µg BPA / kg B.W. plus 10 mg /Kg B.W. All rats within each group received their specific treatment daily with subcutaneous injection starting from the fourth day of pregnancy till full term. Then, the male offsprings of each group were selected and reared until the 60th day after birth. Serum and tissue samples were collected for analyses and microscopical examination. Although prenatal administration of both BPA doses didn’t affect the body weight gain and testicular weights of male offsprings, they reduced significantly the serum levels of testosterone and triodotyrosine when compared to the control group. Also, both BPA doses disturb significantly the oxidant/antioxidant ratio. Moreover, prenatal administration of both BPA doses affected negatively semen quality of the produced offsprings and induced marked histological alterations in their testes and prostate. Remarkably, all serological and histological alterations observed after BPA exposure were ameliorated significantly with MLT co-administration. Thus, prenatal MLT administration could be considered an optimal treatment to relieve many reproductive disorders, degenerative changes of testes and prostate and thyroid malfunction induced in male offsprings after gestational exposure of their dams to BPA.  
Keywords
bisphenol A; Male offspring; Melatonin; testis; testosterone
Statistics
Article View: 308
PDF Download: 324