Spectrofluorimetric determination of some dibenzazepine drugs | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 22, Issue 2, December 1999, Page 191-196 PDF (384.82 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1999.66121 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Horria A. Mohamed; Ibrahim H. Refaat | ||||
| Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy ,Assiut University, Egypt | ||||
| Abstract | ||||
| A convenient and sensitive spectrofluorimetric method for the detn. of 6 dibenzazepine drugs: imipramine-HCl, desipramine-HCl, clomipramine-HCl, trimipramine maleate, opipramol-2HCl and carbamazepine was developed. The method depends on the oxidn. of the compds. with potassium dichromate in acid medium. The relative fluorescence intensities for all 6 drugs were measured at an excitation wavelength range of 350-360 nm and an emission wavelength range of 460-485 nm against a reagent blank prepd. similarly. The drugs could be detd. successfully in the concn. range of 0.1-3.0 μg/mL. The method was satisfactorily applied to their detn. in pharmaceutical prepns. and in spiked plasma samples. The results were in good agreement with those from official methods. | ||||
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