New chiral amine ligands for enantioselective synthesis of certain (S)- and (R)-monobactams | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 5, Volume 23, Issue 2, December 2000, Page 125-136 PDF (3.19 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.2000.66367 | ||||
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Authors | ||||
M. A. Hussein1; A. A. El-Shorbagi* 1; N. M. Omar1; Z. S. Farghaly1; Kiyoshi Tomioka2 | ||||
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71526, Egypt | ||||
2Graduate School of Pharmaceutical Sciences, Department of Synthetic Medicinal Chemistry, Kyoto University, Sakyo-Ku, 606-01, Japan | ||||
Abstract | ||||
Two new tridentate chiral amine ligands I and II mediated the condensation reaction of lithium ester enolate III with benzaldehyde p-anisidineimine IV providing selectively the required (S)- or (R)-monobactam V. It is also noticed that the coexistence of III and chiral lithium amides that formed -in situ- from I,II is an important factor for the enhancement of the reactivity and enantioselectivity of III. | ||||
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