Reduction of some extra-articular complications associated with arthritis development in rats by low dose γ-irradiation
Abd El-fatah, H., Ezz, M., El-kabany, H., ElSonbaty, S. (2020). Reduction of some extra-articular complications associated with arthritis development in rats by low dose γ-irradiation. EKB Journal Management System, 53(1), 172-181. doi: 10.21608/ajnsa.2019.12214.1209
Habiba Abd El-wahab Abd El-fatah; Magda kamal Ezz; Hanan Ahmed El-kabany; sawsan Mohammed ElSonbaty. "Reduction of some extra-articular complications associated with arthritis development in rats by low dose γ-irradiation". EKB Journal Management System, 53, 1, 2020, 172-181. doi: 10.21608/ajnsa.2019.12214.1209
Abd El-fatah, H., Ezz, M., El-kabany, H., ElSonbaty, S. (2020). 'Reduction of some extra-articular complications associated with arthritis development in rats by low dose γ-irradiation', EKB Journal Management System, 53(1), pp. 172-181. doi: 10.21608/ajnsa.2019.12214.1209
Abd El-fatah, H., Ezz, M., El-kabany, H., ElSonbaty, S. Reduction of some extra-articular complications associated with arthritis development in rats by low dose γ-irradiation. EKB Journal Management System, 2020; 53(1): 172-181. doi: 10.21608/ajnsa.2019.12214.1209

Reduction of some extra-articular complications associated with arthritis development in rats by low dose γ-irradiation

Arab Journal of Nuclear Sciences and Applications
Article 18, Volume 53, Issue 1, January 2020, Page 172-181  XML PDF (590.2 K)
Document Type: Original Article
DOI: 10.21608/ajnsa.2019.12214.1209
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Authors
Habiba Abd El-wahab Abd El-fatah email 1; Magda kamal Ezz2; Hanan Ahmed El-kabany3; sawsan Mohammed ElSonbaty4
1Biochemistry,faculty of science, Ain shams university,Cairo, Egypt
2Biochemistry Department, faculty of sciences, Ain shams university
3Health Radiation Research Department, National Center for Radiation Research & Technology, Atomic Energy Authority, Cairo, Egypt
4Radiation Microbiology Department , National Center of Radiation Research and Technology, Atomic Energy Authority
Abstract
Rheumatoid arthritis (RA) is considered a systemic inflammatory disease that affects not only the joints but also other organs in the body causing many extra-articular complications. Low-dose radiation (LDR) modulates a variety of immune responses that have exhibited the properties of immune hormesis. LDR has been used clinically for the treatment of autoimmune diseases. Several molecular mechanisms and cellular components contribute to the clinical efficacy of low dose radiotherapy (LD-RT). The present study aimed to evaluate the possible capability of low dose γ-irradiation to reduce some of these extra-articular complications in adjuvant-induced arthritis model in rats. Our results revealed a significant increase in liver parameters in serum including ALT, AST activities as well as creatinine level in adjuvant induced arthritic rats that indicate liver and kidney impairment respectively. Results also revealed sharp increase in total leukocytic count (TLC). All of these biochemical and hematological disturbances were found to be significantly improved after exposure to low dose γ-irradiation.
Keywords: Rheumatoid arthritis, extra-articular complications, adjuvant induced arthritis, low dose γ-irradiation
Keywords
Keywords: Rheumatoid arthritis; extra-articular complications; adjuvant induced arthritis; low dose γ-irradiation
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