Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma
Hassan, A., El-Sonbaty, S. (2020). Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma. EKB Journal Management System, 53(1), 234-242. doi: 10.21608/ajnsa.2019.66500
Asmaa Hassan; S. M. El-Sonbaty. "Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma". EKB Journal Management System, 53, 1, 2020, 234-242. doi: 10.21608/ajnsa.2019.66500
Hassan, A., El-Sonbaty, S. (2020). 'Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma', EKB Journal Management System, 53(1), pp. 234-242. doi: 10.21608/ajnsa.2019.66500
Hassan, A., El-Sonbaty, S. Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma. EKB Journal Management System, 2020; 53(1): 234-242. doi: 10.21608/ajnsa.2019.66500

Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma

Arab Journal of Nuclear Sciences and Applications
Article 24, Volume 53, Issue 1, January 2020, Page 234-242  XML PDF (771.05 K)
Document Type: Original Article
DOI: 10.21608/ajnsa.2019.66500
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Authors
Asmaa Hassan email orcid 1; S. M. El-Sonbaty2
1Department of Radiation Biology, National Center of Radiation Research and Technology, Atomic Energy Authority, Egypt
2Department of Radiation Microbiology, National Center of Radiation Research and Technology, Atomic Energy Authority, Egypt
Abstract
For many decades the terrestrial plants are represent an infinitive source of bioactive substances  as well as pharmaceutical components which play a main role in the discovering ,developing and manufacturing of anticancer and antibiotic drugs.Solenostemmaargel is a desert plant widely used in Arabic countries as antispasmodic, anti-inflammatory and anti-rheumatic agent. It also has anti-tumor activity. Aim: the present study was oriented to investigatethe hepato-protective effect of fermentedSolenostemmaargelleave extract (100amg/kg b.wt) and/or low dose γ-radiation (0.5Gy) againsthepatocellular carcinoma (HCC)developedin rats by injection of diethylnitrosamine. Results: the data obtained revealed that thepro-apoptotic agents (caspase 3 and cytochrome c) undergoes significant elevation in HCC rats received plant extract and/or γ-radiation compared to HCC rats.While,the vascular endothelial growth factor (VEGF), hypoxia inducible factor-α (HIF-α)and monocytichemotactic protein-1(MCP-1) were significantly decreased. Also, the activity of cyclooxygenase-2 (COX-2) was significantly decreased. Moreover, the histopathological analysis revealed that a mild improvement .In conclusion, the improvement emerged in HCC rats could be attributed to the potency of extract and/or  γ- radiation by induce apoptosis and reduce angiogenesis.
Keywords
Fermented Solenostemmaargel Extract/ Low Dose γ-Radiation/HCC/ Diethylnitrosamine
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