Vitamin D level in nephrotic syndrome, Factors of impact?
Marzouk, H., Ghobrial, E., Khorshied, M., Mohammed, M. (2019). Vitamin D level in nephrotic syndrome, Factors of impact?. EKB Journal Management System, 14(2), 53-61. doi: 10.21608/geget.2019.67042
Huda Marzouk; Emad Ghobrial; Mervat Khorshied; Mona Mohammed. "Vitamin D level in nephrotic syndrome, Factors of impact?". EKB Journal Management System, 14, 2, 2019, 53-61. doi: 10.21608/geget.2019.67042
Marzouk, H., Ghobrial, E., Khorshied, M., Mohammed, M. (2019). 'Vitamin D level in nephrotic syndrome, Factors of impact?', EKB Journal Management System, 14(2), pp. 53-61. doi: 10.21608/geget.2019.67042
Marzouk, H., Ghobrial, E., Khorshied, M., Mohammed, M. Vitamin D level in nephrotic syndrome, Factors of impact?. EKB Journal Management System, 2019; 14(2): 53-61. doi: 10.21608/geget.2019.67042

Vitamin D level in nephrotic syndrome, Factors of impact?

GEGET
Article 9, Volume 14, Issue 2, December 2019, Page 53-61  XML PDF (497 K)
Document Type: Original Article
DOI: 10.21608/geget.2019.67042
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Authors
Huda Marzouk1; Emad Ghobrial email 2; Mervat Khorshied3; Mona Mohammed4
1Kasr Al Ainy School of Medicine, Pediatric department, Cairo University, Cairo, Egypt
2Kasr Al Ainy School of Medicine, Pediatric department, Cairo University, Cairo, Egypt.
3Kasr Al Ainy School of Medicine, Clinical Pathology department, Cairo University, Cairo, Egypt.
4Pediatrics department, Ministry of Health, Cairo, Egypt.
Abstract
Introduction
Nephrotic syndrome (NS) usually responds to steroid therapy; however, the majority of children relapse, resulting in prolonged and repeated courses of steroid therapy. Vitamin D is a vital component of bone metabolism and calcium homeostasis. Maintenance of adequate levels of vitamin D is recommended to maintain good bone health and other organ systems of NS patients. The study aimed to assess serum 25 (OH) D levels in children with NS, compare its level with healthy age and sex-matched controls and compare its level in different types of NS.
 
Patients and Methods
It was a cross-sectional study for measuring 25(OH) D levels in 60 patients with NS and 60 apparently healthy children, to be compared as controls. Nephrotic patients were classified as steroid sensitive (20 cases) steroid dependent (20cases), and steroid resistant (20 cases). Serum 25-hydroxyvitamin [25(OH) D] was measured using Enzyme Linked Immune 
Sorbent Assay (ELISA) technique.
 
Results
Serum 25(OH) D was significantly lower in NS patients than control group (p<0.001).Steroid resistant nephrotic syndrome (SRNS) patient group showed the highest drop than the other 2 groups (p<0.001). There was significant negative correlation between vitamin D level and number of relapses, 24 hours urinary proteins and serum cholesterol.
 
Conclusion
It is recommended that NS patients especially on long term steroid therapy should undergo regular follow up of vitamin D level and early prophylactic supplementation with calcium and vitamin D should be advised.
 
Keywords
nephrotic syndrome; Vitamin D
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