Effect of the combination between empagliflozin and calcipotriol on cadmium-induced testicular toxicity in rats
borg, H., Kabel, A., Estfanous, R., Abd Elmaaboud, M. (2020). Effect of the combination between empagliflozin and calcipotriol on cadmium-induced testicular toxicity in rats. EKB Journal Management System, 40(1), 15-31. doi: 10.21608/besps.2019.14918.1029
hany mohammad borg; Ahmed Kabel; Remon Estfanous; Maaly Abd Elmaaboud. "Effect of the combination between empagliflozin and calcipotriol on cadmium-induced testicular toxicity in rats". EKB Journal Management System, 40, 1, 2020, 15-31. doi: 10.21608/besps.2019.14918.1029
borg, H., Kabel, A., Estfanous, R., Abd Elmaaboud, M. (2020). 'Effect of the combination between empagliflozin and calcipotriol on cadmium-induced testicular toxicity in rats', EKB Journal Management System, 40(1), pp. 15-31. doi: 10.21608/besps.2019.14918.1029
borg, H., Kabel, A., Estfanous, R., Abd Elmaaboud, M. Effect of the combination between empagliflozin and calcipotriol on cadmium-induced testicular toxicity in rats. EKB Journal Management System, 2020; 40(1): 15-31. doi: 10.21608/besps.2019.14918.1029

Effect of the combination between empagliflozin and calcipotriol on cadmium-induced testicular toxicity in rats

Bulletin of Egyptian Society for Physiological Sciences
Article 2, Volume 40, Issue 1, January 2020, Page 15-31  XML PDF (842.56 K)
Document Type: Original Article
DOI: 10.21608/besps.2019.14918.1029
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Authors
hany mohammad borg email 1; Ahmed Kabel2; Remon Estfanous3; Maaly Abd Elmaaboud4
1faculty of medicine, kafrelsheikh university
2Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt
3Physiology department, Faculty of Medicine, Kafrelsheikh University, Egypt
4Anatomy and Embryology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Abstract
The aim of this study was to assess the effect of empagliflozin and/or calcipotriol on cadmium-induced testicular toxicity in rats. Sixty male Wistar rats were divided into 6 equal groups: Control; cadmium; cadmium + empagliflozin; cadmium + calcipotriol; cadmium + Carboxymethyl cellulose and cadmium + empagliflozin + calcipotriol. Testicular enzymes, serum testosterone, luteinizing hormone and follicle stimulating hormone were measured. Also, testicular tissue antioxidant enzymes, interleukin-6 (IL-6), transforming growth factor beta 1 (TGF-β1) and sperm characteristics were determined. Parts of the testes were subjected to histopathological and immunohistochemical examination. Empagliflozin/calcipotriol combination restored the testicular enzymes, sperm characteristics, hormonal profile and the antioxidant defenses compared to the use of each of these drugs alone. Also, this combination significantly ameliorated the inflammatory processes and induced significant improvement of the histopathological, and immunohistochemical picture compared to the use of each of these drugs alone. So, empagliflozin/calcipotriol combination might represent a promising therapeutic modality for amelioration of cadmium-induced testicular toxicity.
Keywords
empagliflozin; Calcipotriol; cadmium; testis; Rats
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