Quercetin mitigates liver injury in a rat model of liver cholestasis | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 6, Volume 40, Issue 1, January 2020, Page 84-95 PDF (722.03 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2019.14512.1026 | ||||
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| Authors | ||||
Noha AbdelAziz Nassef   ; Ebtessam Abu-Shadi; Sahar El Agaty ; Gehad Abdel Hamid
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| Physiology Department, Faculty of Medicine, Ain Shams University | ||||
| Abstract | ||||
| Abstract Background: cholestasis is a prevalent health problem associated with liver oxidative stress, inflammation, and fibrosis. Quercetin has been shown to afford a beneficial effect in a variety of liver diseases.This study was designed to investigate the potential protective effect of quercetin on liver cholestasis and the possible underlying mechanisms in a rat model of bile duct ligation (BDL). Methods: This study was carried out on adult male rats which were randomly divided into: Sham-operated, BDL and BDL- quercetin treated (BDL- Q) groups. Quercetin was given by gavage in a dose of 50 mg/kg/day. Results: Bile duct ligation resulted in a significant increase in serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and liver levels of myeloperoxidase (MPO), tumor necrosis factor alpha (TNF-α),and transforming growth factor beta 1(TGF-β1), along with a significant decrease in serum levels of total proteins (TPs) and liver glutathione peroxidase(GPX) in BDL group versus sham-operated controls. Quercetin treatment significantly lowered serum levels of AST, ALT, ALP, and MPO, TNF-α, and TGF-β1 in liver tissues associated with a significant increase in serum TPs and liver GPX in BDL-Q group versus BDL rats. Histological studies revealed enhancement of inflammation and a significant increase in the percentage area of collagen deposition in BDL versus sham-operated group. These changes were attenuated in BDL-Q group compared to BDL rats. Conclusions: Quercetin alleviated cholestasis induced liver injury and improved liver function possibly via attenuating liver oxidative stress, inflammation and fibrosis. | ||||
| Keywords | ||||
| Cholestasis; Quercetin; Oxidative Stress; Inflammation; fibrosis | ||||
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