Effect of Clodronate Alone or in Combination with Vitamin E on Demineralization Induced by Whole Body Gamma Irradiation in Rats | ||
| Egyptian Journal of Radiation Sciences and Applications | ||
| Article 1, Volume 32, Issue 2, December 2019, Pages 125-136 PDF (2.17 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrsa.2018.4850.1049 | ||
| Authors | ||
| Heba A. Gheita1; Walaa A. Elsabbagh* 1; Rania M. Abdelsalam2; Amina S. Attia2; Mona A. El-Ghazaly1 | ||
| 1Drug Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt | ||
| 2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Giza, Egypt | ||
| Abstract | ||
| BISPHOSPHONATES usually have been chosen in cancer treatment protocols for the management of fractures risk and controlling metastatic bone pain following chemo- and radiotherapy. This study aims at investigating the beneficial effect of clodronate alone or in combination with vitamin E in irradiated rats exposed to 1Gy 3 alternating days/week for 5 weeks. Calcitonin was also studied individually and in combination with vitamin E in order to investigate its possible effect on bone mass in irradiated rats. Irradiated rats treated with clodronate (5mg/kg, s.c., twice a week) or calcitonin (10 IU/kg, s.c., 48hrs) showed significant decreases in urinary hydroxyproline (Hpr), calcium (Ca) and significant increases in urinary phosphorus (Ph) and serum total antioxidant capacity (TAC) levels, while combination with vitamin E normalized most of measured parameters. It could be concluded that vitamin E could synergize the anti-osteoporotic effect of clodronate or calcitonin especially in γ- irradiated cases. | ||
| Keywords | ||
| Clodronate; Calcitonin; Vitamin E; γ- irradiation | ||
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