PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS
Mohamed, F., El-Rabbat, N., Khashaba, P., Farag, H., Bodor, N. (1998). PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS. EKB Journal Management System, 21(1), 41-54. doi: 10.21608/bfsa.1998.67834
F. A. Mohamed; N. El-Rabbat; P. Khashaba; H. H. Farag; N. Bodor. "PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS". EKB Journal Management System, 21, 1, 1998, 41-54. doi: 10.21608/bfsa.1998.67834
Mohamed, F., El-Rabbat, N., Khashaba, P., Farag, H., Bodor, N. (1998). 'PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS', EKB Journal Management System, 21(1), pp. 41-54. doi: 10.21608/bfsa.1998.67834
Mohamed, F., El-Rabbat, N., Khashaba, P., Farag, H., Bodor, N. PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS. EKB Journal Management System, 1998; 21(1): 41-54. doi: 10.21608/bfsa.1998.67834

PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS

Bulletin of Pharmaceutical Sciences Assiut University
Article 6, Volume 21, Issue 1, June 1998, Page 41-54  XML PDF (675.96 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1998.67834
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Authors
F. A. Mohamed1; N. El-Rabbat1; P. Khashaba1; H. H. Farag1; N. Bodor2
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, Florida, USA
Abstract
Certain new monoamine oxidase inhibitors (MAOIs) containing a pyridinium moiety as an integral part of their structures (Q) were designed. The quaternaries, their corresponding 1,4-dihydroxypyridine derivatives (CDS) and their parent pyridine compounds (P) were synthesized. A spectrofluorimetric method was used to test their in vitro monoamine oxidase inhibition. The compounds showed reasonable activities by the test performed. 
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