AMELIORATIVE EFFECT OF CALOTROPIS PROCERA AND/OR PRAZIQUANTEL ON SCHISTOSOMA MANSONI INFECTED MICE
NIGM, A., ABOU ELDAHAB, M., KHALIL, L., JUROUD, R., AZZAM, A., TAHA, H., SOLIMAN, M. (2019). AMELIORATIVE EFFECT OF CALOTROPIS PROCERA AND/OR PRAZIQUANTEL ON SCHISTOSOMA MANSONI INFECTED MICE. EKB Journal Management System, 49(3), 529-538. doi: 10.21608/jesp.2019.68055
AHMED H. NIGM; MARWA ABOU ELDAHAB; LOTFIA M. KHALIL; RAHMA B. M. JUROUD; AHMAD M. AZZAM; HODA A. TAHA; MOHAMMAD I. SOLIMAN. "AMELIORATIVE EFFECT OF CALOTROPIS PROCERA AND/OR PRAZIQUANTEL ON SCHISTOSOMA MANSONI INFECTED MICE". EKB Journal Management System, 49, 3, 2019, 529-538. doi: 10.21608/jesp.2019.68055
NIGM, A., ABOU ELDAHAB, M., KHALIL, L., JUROUD, R., AZZAM, A., TAHA, H., SOLIMAN, M. (2019). 'AMELIORATIVE EFFECT OF CALOTROPIS PROCERA AND/OR PRAZIQUANTEL ON SCHISTOSOMA MANSONI INFECTED MICE', EKB Journal Management System, 49(3), pp. 529-538. doi: 10.21608/jesp.2019.68055
NIGM, A., ABOU ELDAHAB, M., KHALIL, L., JUROUD, R., AZZAM, A., TAHA, H., SOLIMAN, M. AMELIORATIVE EFFECT OF CALOTROPIS PROCERA AND/OR PRAZIQUANTEL ON SCHISTOSOMA MANSONI INFECTED MICE. EKB Journal Management System, 2019; 49(3): 529-538. doi: 10.21608/jesp.2019.68055

AMELIORATIVE EFFECT OF CALOTROPIS PROCERA AND/OR PRAZIQUANTEL ON SCHISTOSOMA MANSONI INFECTED MICE

Journal of the Egyptian Society of Parasitology
Article 6, Volume 49, Issue 3, December 2019, Page 529-538  XML PDF (633.29 K)
Document Type: Original Article
DOI: 10.21608/jesp.2019.68055
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Authors
AHMED H. NIGM1; MARWA ABOU ELDAHAB1; LOTFIA M. KHALIL2; RAHMA B. M. JUROUD3; AHMAD M. AZZAM4; HODA A. TAHA1; MOHAMMAD I. SOLIMAN1
1Faculty of Science, Ain Shams University, Cairo 11566, Egypt.
2Faculty of Education, El Zawia University, Libya.
3Faculty of Science, El Mergab University, Libya.
4Theodor Bilharz Research Institute, Egypt.
Abstract
Seventy albino mice were infected with~ 80 S. mansoni cercariae and were classified into: GI: infected non-treated group, GII: treated with C. procera alcoholic extract after infection (therapeutic), GIII: treated with C. procera aqueous extract after infection (therapeutic), GIV: treated with C. procera alcoholic extract before infection (prophylactic alcoholic), GV: treated with C. procera aqueous extract before infection (prophylactic aqueous), GVI: treated with praziquantel, treated group with praziquantel combined with aqueous extract of C. procera and G.VII: infected and treated with half dose of Praziquantel combined with aqueous plant extract. Seven weeks post infection, all mice were autopsied, and livers and ilea were parasitological examined (Tissue egg load) and histological assessments (Number & size of hepatic granulomas). Schistosomes recovered from all groups were processed to calculate total worm burdens. The results showed that mice treated with C. procera alcoholic and aqueous extracts showed more significant reduction in total worm burden (43.7% & 46.4%), total egg tissue load (60% & 50.7%) and number of hepatic granuloma (45.9% & 55.5%) than mice in prophylactic aqueous or alcoholic groups (38.3% & 36%, 27.2% & 44%, 25.6% & 39%, respectively). Female worms
recovered from mice of aqueous or alcoholic treated groups showed less fecundity than those recovered from mice of prophylactic groups (1475±181 & 2821±200, corresponding to 3674±1447 & 3023±709, respectively). Mice treated with praziquantel or treated with praziquantel combined with C. procera aqueous extract showed the highest reduction in total tissue egg load (86.4% & 97.4%, respectively). Mice treated with praziquantel combined with C. procera aqueous extract showed higher reduction in total egg tissue (97.4%), number and size of hepatic granuloma (72.3% & 31.4%) than those treated with praziquantel (86.4%, 55.5% &10.8%, respectively).
Keywords
Schistosoma mansoni; Albino mice; Calotropis procera; praziquantel
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