IMMUNOMODULATORY EFFECTS OF PAEONIFLORIN COMBINED TO SOLUBLE EGG ANTIGENS IN SCHISTOSOMIASIS MANSONI MURINE MODEL | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 6, Volume 49, Issue 2, August 2019, Page 293-300 PDF (463.67 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2019.68133 | ||||
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| Authors | ||||
| NAGLAA FATHY ABD EL-AAL1; EMAN HASSAN ABD ELBARY2 | ||||
| 1Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Egypt. | ||||
| 2Department of Pathology, Faculty of Medicine, Zagazig University, Egypt. | ||||
| Abstract | ||||
| Praziquantel, the main schistosomiasis chemotherapy; cannot fully counteract the infection associated morbidity including hepatic fibrosis and its sequelae. A novel therapeutic strategy is mandatory. The current study is a novel trial to assess the immunomodulatory effect of Paeoniflorin (PAE) in combination to soluble egg antigen (SEA) in schistosomiasis mansoni murine model through; parasitological, histopathological, immunohistochemical and serological studies aiming to synergistic effect that not only eliminate the parasite but also ameliorate morbidity associated to infection. Forty laboratory bred Swiss albino male CD-1 mice were used. The mice were classified into five groups (8 mice each), control healthy, control infected, PAE treated (50 mg/kg/d), SEA vaccinated (50μ protein) and combined (PAE+SEA) groups. All mice groups were sacrified 10 weeks post infection. Our results showed marked decrease in egg count/gm stool, worm burden, granuloma diameter, tissue transforming growth factor-beta1 (TGF-β ) serum interleukin-13 (IL-13) associated with marked increase in the serum interferon-gamma (INF-γ) level in (PAE+SEA) combined group compared to all groups. | ||||
| Keywords | ||||
| Schistosoma mansoni; fibrosis; Cirrhosis; PZQ; Cytokines; IL-13; INF-γ; TGF-β1 | ||||
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