SEROLOGY OF THE SYSTEMIC LUPUS ERYTHEMATOSUS IN EGYPTIAN PATIENTS | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 18, Volume 49, Issue 2, August 2019, Page 401-404 PDF (417.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2019.68159 | ||||
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| Authors | ||||
| ALYAA A. FARID1; RWAN A. EISSA2; AHMED M. NADA2; MONA M. ELAMIR2; AZZA M. ELAMIR1 | ||||
| 1Faculty of Science, Cairo University, Giza, Egypt. | ||||
| 2Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th October, Egypt. | ||||
| Abstract | ||||
| Systemic lupus erythematosus (SLE) is a prototypic multisystem autoimmune disease with a vast spectrum of clinical presentations including almost all body organs and tissues. The incidence of lupus has tripled in the last 40 years, mainly due to the improved diagnosis. For more than 60 years the presence of autoantibodies in patients with SLE has been known. A great effort is being made for understanding the diagnostic, pathogenic and prognostic meaning of these autoantibodies. The study demonstrated the significance of autoantibodies test in Egyptian SLE patients. The results showed that 93.3% of patients have positive ANA test, 90% have positive anti-dsDNA. Anti-Sm antibodies were in 40% and 49.3% of patients have positive anti-nucleosome antibody test. Also, 30.6% of patients deve-loped a positive anti-histone test & 26% have positive anti-ribosomal test. Anti-phospholipids antibodies were found in 44.6% of patients. Levels of C3 & C4 (0.552±0.43 & 0.125±0.12, respectively) were lower than that of control group (1.2±0.35 & 0.42±0.54 for C3 & C4, respectively). | ||||
| Keywords | ||||
| Egypt; Systemic lupus erythematosus; Autoantibodies test | ||||
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