Assessment of Intravenous Lipid Emulsion as an Adjuvant Therapy in Acute Aluminum Phosphide Poisoning: A randomized Controlled Trial | ||||
| Ain Shams Journal of Forensic Medicine and Clinical Toxicology | ||||
| Article 6, Volume 34, Issue 1, January 2020, Page 51-68 PDF (1.47 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajfm.2020.68225 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Samar ELabdeen; Khaled Saad; Mervat Oreby; Fatma Elgazzar | ||||
| Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt. | ||||
| Abstract | ||||
| Background: Aluminum phosphide (ALP) is efficient rodenticide and insecticide. The increased incidence of acute ALP poisoning and its high mortality is a challenge for health professionals, there is no specific antidote and the treatment is mainly supportive. Aim of the work: The aim of this study was to evaluate the efficacy and safety of intravenous lipid emulsion as an adjuvant therapy for acute ALP poisoning. Patients and methods: The present study was carried out on fifty patients with acute ALP poisoning admitted at Poison Control Unit, Tanta University Emergency Hospital, throughout a period from the start of December 2016 till November 2017. The study participants were randomly allocated into 2 equal groups (25 patients each): The experimental group (received ILE 20% at a rate of 10ml/h IV infusion plus the conventional treatment of ALP poisoning), and the control group (received the conventional treatment only). Results: The number of deaths in the experimental group was lower than the control group, but it did not reach a significant level. The need for intubation and mechanical ventilation was significantly lower in the experimental group compared to the control group. Conclusion: The administration of ILE 20% in acute ALP poisoning at a rate of 10ml/h IV infusion is a safe therapy. Moreover, the adjuvant ILE use along with the conventional supportive treatment could have a therapeutic effect in ALP poisoned patients. | ||||
| Keywords | ||||
| Aluminum phosphide; grain tablet; Intravenous Lipid Emulsion; clinical trial | ||||
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