CHARACTERIZATION OF HLA-DRB1 ALLELES POLYMORPHISMS IN PLASMODIUM FALCIPARUM MALARIA INFECTIONS IN JAZAN, KSA
ZAKI, W., RAYAN, H., MADKHALY, A., MADKHALY, K. (2019). CHARACTERIZATION OF HLA-DRB1 ALLELES POLYMORPHISMS IN PLASMODIUM FALCIPARUM MALARIA INFECTIONS IN JAZAN, KSA. EKB Journal Management System, 49(1), 173-182. doi: 10.21608/jesp.2019.68299
WAFAA M. ZAKI; HANAN Z. RAYAN; AYMEN M. MADKHALY; KHAWLAA M. MADKHALY. "CHARACTERIZATION OF HLA-DRB1 ALLELES POLYMORPHISMS IN PLASMODIUM FALCIPARUM MALARIA INFECTIONS IN JAZAN, KSA". EKB Journal Management System, 49, 1, 2019, 173-182. doi: 10.21608/jesp.2019.68299
ZAKI, W., RAYAN, H., MADKHALY, A., MADKHALY, K. (2019). 'CHARACTERIZATION OF HLA-DRB1 ALLELES POLYMORPHISMS IN PLASMODIUM FALCIPARUM MALARIA INFECTIONS IN JAZAN, KSA', EKB Journal Management System, 49(1), pp. 173-182. doi: 10.21608/jesp.2019.68299
ZAKI, W., RAYAN, H., MADKHALY, A., MADKHALY, K. CHARACTERIZATION OF HLA-DRB1 ALLELES POLYMORPHISMS IN PLASMODIUM FALCIPARUM MALARIA INFECTIONS IN JAZAN, KSA. EKB Journal Management System, 2019; 49(1): 173-182. doi: 10.21608/jesp.2019.68299

CHARACTERIZATION OF HLA-DRB1 ALLELES POLYMORPHISMS IN PLASMODIUM FALCIPARUM MALARIA INFECTIONS IN JAZAN, KSA

Journal of the Egyptian Society of Parasitology
Article 21, Volume 49, Issue 1, April 2019, Page 173-182  XML PDF (486.75 K)
Document Type: Original Article
DOI: 10.21608/jesp.2019.68299
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Authors
WAFAA M. ZAKI1, 2; HANAN Z. RAYAN1, 2; AYMEN M. MADKHALY2; KHAWLAA M. MADKHALY2
1Department of Medical Parasitology, Faculty of Medicine, Suez Canal University, Ismalia, Egypt.+
2Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University Jazan, Kingdom of Saudi Arabia.
Abstract
Malaria is a public health problem in the KSA. It is restricted to the southwestern region, where P. falciparum is the most prevalent species. The immune response which affects the clinical outcome of malaria is genetically controlled and is influenced with high degree of HLA genetic polymorphism. The present study aimed at assessing the relationship between HLA-DRB1 alleles and malaria susceptibility pattern moreover its degree of severity in a group of Saudi population in Jazan, KSA. A total of 60 malaria cases (51 uncomplicated and 9 severe malaria cases) and 60 control subjects were enrolled in this study. Blood samples were collected and genotyping of the HLA-DRB1 alleles was performed. The results suggested significant associations of HLA-DRB1* 04 and HLA-DRB1* 11 with susceptibility to malaria (p = 0.002 and p = 0.043, respectively) and association of HLA-DRB1* 13 with resistance to malaria (p = 0.032). The HLA-DRB1* 04 was found to be associated with severe malaria. The individuals with HLA-DRB1* 04 and HLA-DRB1* 11 were at increased risk to malaria infection and the HLA-DRB1* 04 carriers are more susceptible to severe malaria. While, HLA-DRB1* 13
carriers are more resistant to this infection. Wide investigations for this association may lead to implementation
of a successful effective malaria vaccine program.
Keywords
Saudi Arabia; Plasmodium falciparum; HLA-Drb1 Alleles Polymorphisms
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